ID   V6JWN6_STRNV            Unreviewed;       524 AA.
AC   V6JWN6;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Histidine ammonia-lyase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=M877_25480 {ECO:0000313|EMBL:EST24330.1};
OS   Streptomyces niveus NCIMB 11891.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST24330.1, ECO:0000313|Proteomes:UP000017971};
RN   [1] {ECO:0000313|EMBL:EST24330.1, ECO:0000313|Proteomes:UP000017971}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST24330.1,
RC   ECO:0000313|Proteomes:UP000017971};
RX   PubMed=24407644;
RA   Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT   "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT   Aminocoumarin Antibiotic Novobiocin.";
RL   Genome Announc. 2:e01146-e01113(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST24330.1}.
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DR   EMBL; AWQW01000176; EST24330.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6JWN6; -.
DR   STRING; 193462.BBN63_21275; -.
DR   PATRIC; fig|1352941.4.peg.5187; -.
DR   eggNOG; COG2986; Bacteria.
DR   HOGENOM; CLU_014801_4_2_11; -.
DR   Proteomes; UP000017971; Chromosome.
DR   GO; GO:0016841; F:ammonia-lyase activity; IEA:UniProt.
DR   CDD; cd00332; PAL-HAL; 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   InterPro; IPR001106; Aromatic_Lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR   PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR   Pfam; PF00221; Lyase_aromatic; 1.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
PE   4: Predicted;
FT   REGION          497..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..524
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  54024 MW;  581AE18776720B31 CRC64;
     MPDRRPAPAR PALVVLDGQS LPVADIVRLA DGAARPVPGT GAMKRVEQSW HTARELAASG
     RVYGRSTGVG ANRAEAVPSE AAADHGLRLL RSHAGAVGNP LPAREVRAML AVRANQLLAG
     GAGLRPTVVG ALCDALAAGA HPVVNEFGSV GTGDIAALSQ LGLALVGEHP WQGGRPPEAQ
     PLDNNDALAL ISSNALTLGQ AALALDELGR LIAATELVAA LSLLAVDGSY EAYAEPVHAA
     RPHPGSYAVA TRMRRILGAP GRPTPPLGRI QDPYGFRCLP QVHGPARDAA DALERALAVE
     INSAAENPLI CPGSDDDLAP AAYHHGGFYL AQLALALDHF RLAVVQTARL SSSRLSALNE
     PGLTRLRPFL ADAEPASSGV MILEYAAGAA LGDLRAFSAP ASLGHAVLSR GVEEQASFAS
     LAARQTLRAC EAYRLVVGCE LVAAVRALRQ RDLRPEAALP VGRAFALAES VLDPEIADRP
     LTEDVMAAAR LLDQLATTDD DMSGTGSPGS PGSTGMTGTT RGIA
//