ID V6KAK5_STRRC Unreviewed; 325 AA.
AC V6KAK5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=2-oxoisovalerate dehydrogenase subunit beta {ECO:0000313|EMBL:EST29165.1};
GN ORFNames=M878_21135 {ECO:0000313|EMBL:EST29165.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST29165.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST29165.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST29165.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST29165.1}.
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DR EMBL; AWQX01000183; EST29165.1; -; Genomic_DNA.
DR RefSeq; WP_023548341.1; NZ_CM002285.1.
DR AlphaFoldDB; V6KAK5; -.
DR STRING; 1352936.M878_21135; -.
DR PATRIC; fig|1352936.5.peg.4430; -.
DR HOGENOM; CLU_012907_1_0_11; -.
DR OrthoDB; 3457658at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR CDD; cd07036; TPP_PYR_E1-PDHc-beta_like; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR033248; Transketolase_C.
DR PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017984}.
FT DOMAIN 5..180
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 325 AA; 35619 MW; 9CF1A72288701499 CRC64;
MAEKMAMAKA INESLRRALE TDPKVLVMGE DVGKLGGVFR VTDGLQKDFG ESRVIDTPLA
ESGIVGTAIG LALRGYRPVV EIQFDGFVFP AYDQIVTQLA KMHARSLGKV KMPVVIRIPY
GGGIGAVEHH SESPEALFAH VAGLKVVSPS NASDAYWMMQ QAIQSDDPVI YFEPKRRYWD
KAEVDAEAIP APLHKAQVVR EGTDLTLAAY GPMVKLCREV ADAAAEEGKS LEIVDLRSVS
PLDFDTVQAS VEKTRRLVVV HEAPVFFGSG AEIAARITER CFYHLEAPVL RVGGYHAPYP
PARLEEEYLP DLDRVLDAVD RSLAY
//
