ID V6KB07_STRNV Unreviewed; 729 AA.
AC V6KB07;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Membrane transport protein MMPL domain-containing protein {ECO:0000259|Pfam:PF03176};
GN ORFNames=M877_12400 {ECO:0000313|EMBL:EST29345.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST29345.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST29345.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST29345.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST29345.1}.
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DR EMBL; AWQW01000089; EST29345.1; -; Genomic_DNA.
DR RefSeq; WP_023538744.1; NZ_CM002280.1.
DR AlphaFoldDB; V6KB07; -.
DR STRING; 193462.BBN63_10445; -.
DR PATRIC; fig|1352941.4.peg.2534; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_5_2_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 199..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 244..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 540..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 564..585
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..710
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..381
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 423..720
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 51..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 76097 MW; 992B42A3CA5D0DC3 CRC64;
MLRRIKSERP HAGLVESVTG WSARNRTAAI AAWLLLVVVA VLSTSLLPGE QVRSTEPGEA
GRGQRMVSAQ DAGDSIRENV MIRAGAGRAP ETRRAVTDDL VAALRAIPDA VQDVGSPLGA
HGGRWVSGDG TADLVTFEIA GPGAEFDTHR QTAFDAVGKV ARQHPEARLD QAGDSSLASA
VDQGIKDDMK RAETTSLPLT VVILLVVFGS LVAAGIPFLL SATAVAAAFG LLETLGRWVP
FNSAASAIVL LIGMAVGIDY SLFYLRRIRE ERAAGRGVQE ALRIASRTSG HAVVVSGLTV
MVCMTGLLFT GVDVFKGLTL GTVLVVGLAV LGSVTVLPAL VAALGDRIDL GRIPWLGRRR
TAAGRSRIWT AVARRVVRRP LLTGGTAALL LAVMALPAFG MHLQDATQIQ SLPRGVSAAA
DAGARMQRVF PGVATPARVV VSDNGPKARA AADALHEQAA RSDGALREPI TAVPVGDLLV
VRVPLAGAGT DPESARALEF LRERAVPATV GAVEGVEVAV AGRTATPYDF TRQVNARTPV
VFAFVLVLAF VLLVVAFRSL ALPLVSIALN LLSIGAAYGV LVAVFQGGRL ESLLDFNAYG
GVVSWLPLFM FVILFGLSMD YHIFILSRIR ERWAGSRGGP DGGHEAVVGG IAVSAGVVTS
AAAIMVGVFS VFTTLSAIEY KMLGTGMAVA ILIDATVVRG VLLPAALALL GERAWTLPGR
GDSGLRTRK
//
