ID V6KRP6_STRNV Unreviewed; 420 AA.
AC V6KRP6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=M877_06660 {ECO:0000313|EMBL:EST31654.1};
OS Streptomyces niveus NCIMB 11891.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352941 {ECO:0000313|EMBL:EST31654.1, ECO:0000313|Proteomes:UP000017971};
RN [1] {ECO:0000313|EMBL:EST31654.1, ECO:0000313|Proteomes:UP000017971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCIMB 11891 {ECO:0000313|EMBL:EST31654.1,
RC ECO:0000313|Proteomes:UP000017971};
RX PubMed=24407644;
RA Flinspach K., Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces niveus NCIMB 11891, Producer of the
RT Aminocoumarin Antibiotic Novobiocin.";
RL Genome Announc. 2:e01146-e01113(2014).
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST31654.1}.
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DR EMBL; AWQW01000047; EST31654.1; -; Genomic_DNA.
DR RefSeq; WP_023537626.1; NZ_CM002280.1.
DR AlphaFoldDB; V6KRP6; -.
DR STRING; 193462.BBN63_00115; -.
DR REBASE; 78438; M.Sni11891ORF6660P.
DR PATRIC; fig|1352941.4.peg.1366; -.
DR eggNOG; COG0270; Bacteria.
DR HOGENOM; CLU_052980_0_0_11; -.
DR OrthoDB; 9813719at2; -.
DR Proteomes; UP000017971; Chromosome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 3.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT REGION 230..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..297
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 69
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 420 AA; 45482 MW; 5E7E6BE277667196 CRC64;
MILDLFAGPG GWSHSLTVLG VRDVGLEWDQ WACKTRALAG QLTIRTDVAM YPVWPFVGRT
YGLIASPPCQ AWSMAGKRLG LLDQPLVHQA VADLAQGRDT RERLLASCQD ERSLLAAEPM
RYLHALNTVD EPEWVVMEEV PDVLPLWKQY AAILRAWGFS VWTGILNAAD YGVPQTRRRA
ILLASRVRTA EPPAPTHAQA AEPESLFGPG RAQWVSMATA LGWGATDRPV PTVCAGGGPG
GGPEPFPSGS RKTLTDARDR GTWTPRAAGS PRSPQREDSG RPAPSATRDD RPVEEAVTAG
AHRWSWSLRS NNQAKATIRP LSEPAGTLFF GHRANECVWV PEPSEPRRAD GGQVVVPESI
RITAREAGLL QTFPAGYPWA GNKGQQFSQI GNAVPPLLAA HLLAPHLQLP LDPDNFTLAA
//
