ID   V6KWX2_9ACTN            Unreviewed;       855 AA.
AC   V6KWX2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|SMART:SM00849};
GN   ORFNames=N566_17090 {ECO:0000313|EMBL:EST35921.1};
OS   Streptomycetaceae bacterium MP113-05.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae.
OX   NCBI_TaxID=1380770 {ECO:0000313|EMBL:EST35921.1, ECO:0000313|Proteomes:UP000017915};
RN   [1] {ECO:0000313|EMBL:EST35921.1, ECO:0000313|Proteomes:UP000017915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP113-05 {ECO:0000313|EMBL:EST35921.1,
RC   ECO:0000313|Proteomes:UP000017915};
RA   Valde M., Degnes K.F., Sletta H., Ruckert C., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces bacterium from a marine sponge: physiological
RT   characterization and genome-based analysis of secondary metabolite
RT   biosynthesis potential.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST35921.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AWQV01000562; EST35921.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6KWX2; -.
DR   STRING; 1380770.N566_17090; -.
DR   PATRIC; fig|1380770.3.peg.2967; -.
DR   HOGENOM; CLU_010363_4_0_11; -.
DR   Proteomes; UP000017915; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017915};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        48..81
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        93..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        337..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        442..467
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        473..495
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        502..522
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        534..552
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        559..577
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          600..800
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          835..855
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   855 AA;  87294 MW;  ED2009FEF7045DB6 CRC64;
     MTPGPTVAAA RPAAAFRGPV HRASPNPLGA ADPRQEGPPD LRLVPPALTA WAAAALAPAL
     PALATAVAVA SCCLLASVLA FRRRRSTDPP RWYGNRLVAA MTLICAAAGA ASAALHAVDA
     RRGPVPGLAA DHATTSVELT VTGDPHRAEP RVIGTRRVPG VLVVPVDVTR VTVPATAQHV
     AVHTPALLLV DADDGTASRW GRLLPSTGIR VEARFAPPRP RGGGRDVAAV LRTGGKDPPV
     VLAPPTTPQR VAGDLRAGLR EATGELAPDP RALLPGLVVG DTSRIPEDLD EAFHTTDMLH
     LLAVSGGNLT VLLVLLIGPP GRASLAERRG LAPRLGLPLR ATAVLAALVV LGFVLVCRPQ
     PSVLRAAACG LITILAIGTG RRRSLIPALA AAVLLLVLHD PGLAREAGFL LSVLATGSLL
     TVAPRWSLAL RRHGIPGRLA EALAAAAAAQ AACAPVVAVL AAHISLVAVP CNLLAEFAVA
     PATVLGFAAL LAAPLSPALA EGLARLGGLP AAAIALIART GASVPGATFP WPDTWPGALL
     LALLVGAMLI LGRRLTAHPW LCAATALLLL LALVRPAPLT RPLTGWPPDG WLLVTCDVGQ
     GDAIVLAAGD GTAALVDTGP EPDAVDDCLT SLGVTRIPFL LLTHFHADHV AGLPGALRGR
     TVGAIRATGV QEPSAQAEFV HRVARRAGVP LVRAAAGGRG SLGPLSWQVV WPPAGRPSSV
     AADGEDVANN ASVTLLVRVA GLTVLLPGDL EPPAQRRLLE DLPGLGPVDV LKVAHHGSAY
     QDPALLARLD PRIALISAGT GNPYGHPSPH TLRRLHHRGA LVRRTDTSGP LAVTVTPDGT
     PAVTTARSPP GPRPG
//