ID   V6KY30_9ACTN            Unreviewed;       755 AA.
AC   V6KY30;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Diguanylate phosphodiesterase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=N566_15790 {ECO:0000313|EMBL:EST36913.1};
OS   Streptomycetaceae bacterium MP113-05.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae.
OX   NCBI_TaxID=1380770 {ECO:0000313|EMBL:EST36913.1, ECO:0000313|Proteomes:UP000017915};
RN   [1] {ECO:0000313|EMBL:EST36913.1, ECO:0000313|Proteomes:UP000017915}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP113-05 {ECO:0000313|EMBL:EST36913.1,
RC   ECO:0000313|Proteomes:UP000017915};
RA   Valde M., Degnes K.F., Sletta H., Ruckert C., Kalinowski J., Zotchev S.B.;
RT   "Streptomyces bacterium from a marine sponge: physiological
RT   characterization and genome-based analysis of secondary metabolite
RT   biosynthesis potential.";
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST36913.1}.
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DR   EMBL; AWQV01000523; EST36913.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6KY30; -.
DR   STRING; 1380770.N566_15790; -.
DR   PATRIC; fig|1380770.3.peg.2743; -.
DR   HOGENOM; CLU_000445_70_50_11; -.
DR   Proteomes; UP000017915; Unassembled WGS sequence.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 1.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013656; PAS_4.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR   PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   Pfam; PF08448; PAS_4; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017915}.
FT   DOMAIN          156..226
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          230..282
FT                   /note="PAC"
FT                   /evidence="ECO:0000259|PROSITE:PS50113"
FT   DOMAIN          321..455
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          464..730
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
FT   REGION          726..755
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   755 AA;  82497 MW;  64D49BE1D1855B5D CRC64;
     MSSAPQLKGT AADGLRRFAT IWSRAVYPAT ATSMTRAEFE DHLYPLAVRL GEALHSHPFT
     PAPGREVGEA LVGAHCTAPD ALPQILGVVE SYLVLYSSEK TSLPVEEGRA RCSRLQHAVA
     AGFAKALRER TRSEQEALSR AALAAQAAVE EALHTSETRF RTVFKDATIG IGIADMDGRI
     RDVNGALARM FNASEEELRR RNVSEWVHPS DAPEVWRMHR ELVRGARDHF RVEKPYHRPD
     GTVLWTNLTV SLLRGAEGEP RYQLALMEDI TERRLLHLRL RYEATHDELT GLPNRTLFAE
     RLERVLAGTG PASRGEGGRS GRFGLLYLDI DGFKAVNDSL GHAVGDQLLV SVAERLQSCA
     AAPNQLVARI GGDEFVALIS NPTGREEVVE LARQALAALA TPIAIDGREL SVRASIGIVE
     GRNGKLGPAE VLRSADITMY RAKDAGGNRY ETADPVSDAQ AIDRHSLTTH LPGALERGEF
     FLEYQPLIRM KDSRLIGAEA LVRWRHPVHG RLGPDRFIPL AEHTGLIVPL GRWVLEQAAR
     QAADWCAHPV LGACAEDGAP IRVNVNLSPR QLHHPDLVQD TVAVLERAGL TPASLCLEVT
     ESALIGADED ELKPLRQLAE MGVDIALDDF GTGYSNLAYL SRLPVRALKL DGTFVRGFRT
     ERHENPADET IVAALVQLAH ELGLTVTAEC VEGQEQAERL RGIGCDTGQG YYYARPMPAP
     SLSAWLARAP RDDGPRRPRT RPSFGPTPTG GRKTA
//