ID V6KZ60_STRRC Unreviewed; 779 AA.
AC V6KZ60;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Kinase {ECO:0000313|EMBL:EST34264.1};
GN ORFNames=M878_10945 {ECO:0000313|EMBL:EST34264.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST34264.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST34264.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST34264.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST34264.1}.
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DR EMBL; AWQX01000083; EST34264.1; -; Genomic_DNA.
DR AlphaFoldDB; V6KZ60; -.
DR STRING; 1352936.M878_10945; -.
DR PATRIC; fig|1352936.5.peg.2319; -.
DR HOGENOM; CLU_012300_4_1_11; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EST34264.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EST34264.1}.
FT DOMAIN 103..200
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 477..538
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 700..774
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 779 AA; 83223 MW; 8FD16DB5E193FBD8 CRC64;
MSAEATNPAS PGPVAPTASA AATAPAVPRA DRRKSRPRID LRRLGRAALL GPAVRGKLPD
AIGHVVEAHR AHHPDADLDP LRRAYVLAES SHRGQMRKSG EPYITHPLAV TLILAELGAE
TTTLTASLLH DTVEDTDVTL DQVREQFGEE VRYLVDGVTK LEKVDYGAAA EPETFRKMLV
ATGSDVRVMS IKLADRLHNM RTLGVMRPEK QARIAKVTRD VLIPLAERLG VQALKTEMED
LVFAILHPEE YEHTRELIAD NAARPDDPLA EVADEMRRVL REAGIQAEVL IRPRHFVSVH
RVARKRGQLR GTDFGRLLVL VHEDADCYGV LGELHTCMTP VVSEFKDFIA VPKFNLYQSL
HTAVAVPQAR TDSPGGTPIA AQVVEVLIRT HQMHKVAEAG VIALGNPYAP APDATASDAT
ASGATVSDAS ASDAPADGER ADPTRPGWLS RLLDWQEAAP DPDTFWSTLR EDLAQDREIT
VFRPDGGTLG LPEGATCVDA AYAQYGEDAH ACIGARVNSR LATLSTVLKD GDTVQLLMGQ
DPASEPSREW LEHAHTPAAR IAIQRWLATH PSGGSGTDDG SGPRSEPAEA TASQRSAGGS
RADAAGATAS ADAPGGAAPA ERTSAARPRG ADVLVDRPGA AVRLAGCCTP VPPDEITGFA
VRGGVVTVHR LECASVAHMK GRGRTELGVR WGDTSECRVT LVAESFGRPH LLADLTEAIS
STGVDIVSAT VEPPSQQRVR HTYTLQLPDA AHLPALMRAM RDVPGVYDVS RAQHQAPPS
//
