ID V6L265_STRRC Unreviewed; 395 AA.
AC V6L265;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EST35304.1};
GN ORFNames=M878_06315 {ECO:0000313|EMBL:EST35304.1};
OS Streptomyces roseochromogenus subsp. oscitans DS 12.976.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1352936 {ECO:0000313|EMBL:EST35304.1, ECO:0000313|Proteomes:UP000017984};
RN [1] {ECO:0000313|EMBL:EST35304.1, ECO:0000313|Proteomes:UP000017984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DS 12.976 {ECO:0000313|EMBL:EST35304.1,
RC ECO:0000313|Proteomes:UP000017984};
RX PubMed=24407645;
RA Ruckert C., Kalinowski J., Heide L., Apel A.K.;
RT "Draft Genome Sequence of Streptomyces roseochromogenes subsp. oscitans DS
RT 12.976, Producer of the Aminocoumarin Antibiotic Clorobiocin.";
RL Genome Announc. 2:e01147-e01113(2014).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EST35304.1}.
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DR EMBL; AWQX01000055; EST35304.1; -; Genomic_DNA.
DR RefSeq; WP_023545257.1; NZ_CM002285.1.
DR AlphaFoldDB; V6L265; -.
DR STRING; 1352936.M878_06315; -.
DR PATRIC; fig|1352936.5.peg.1352; -.
DR HOGENOM; CLU_031026_2_2_11; -.
DR OrthoDB; 1402717at2; -.
DR Proteomes; UP000017984; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020615; Thiolase_acyl_enz_int_AS.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43853; 3-KETOACYL-COA THIOLASE, PEROXISOMAL; 1.
DR PANTHER; PTHR43853:SF2; 3-OXOADIPYL-COA_3-OXO-5,6-DEHYDROSUBERYL-COA THIOLASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00098; THIOLASE_1; 1.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000017984};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EST35304.1}.
FT DOMAIN 7..265
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..394
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 90
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 351
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 381
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 395 AA; 41555 MW; D6DF129530CBD750 CRC64;
MRPVHFAAAR RTPIGKLRGA LSSVRPDDLA AGVIRQLVAE VPGLDPARID DVYWGAANQA
GEDNRNVARM AALLAGLPDS VPGATVNRLC ASGLEAVTTA ARTVAAGEAD IVIAGGSESM
SRAPFVLPRP DEALPQRIET YDTRLGWRLV NPAMTELHGL LSMGETAEEV AGRYGISRER
QDEFALRSHR LAAAARKNGH FDDELLPVER PDGITVEQDE CVREDTSLEK LSRLKPVFRR
GGTVTAGNAS PMNDGAAGLL LVSEEALNEL GLESLGRYVA GASAGVHPDV MGIGPVPATR
KALARAGWDI ADLQEAEFNE AFAAQALACV DALGIDPDLV NPTGGAIALG HPLGCSGARI
LTTLLHRMRR TGAERGLATM CVGVGQGSAV LVERH
//
