ID V6LJN2_9EUKA Unreviewed; 4677 AA.
AC V6LJN2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EST44588.1};
GN ORFNames=SS50377_15593 {ECO:0000313|EMBL:EST44588.1}, SS50377_24707
GN {ECO:0000313|EMBL:KAH0572596.1};
OS Spironucleus salmonicida.
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC Spironucleus.
OX NCBI_TaxID=348837 {ECO:0000313|EMBL:EST44588.1};
RN [1] {ECO:0000313|EMBL:KAH0572596.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0572596.1};
RX PubMed=24516394;
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 10:E1004053-E1004053(2014).
RN [2] {ECO:0000313|EMBL:EST44588.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 0:0-0(2014).
RN [3] {ECO:0000313|EMBL:KAH0572596.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0572596.1};
RA Xu F., Kurt Z., Jimenez-Gonzalez A., Astvaldsson A., Andersson J.O.,
RA Svard S.G.;
RT "New Spironucleus salmonicida genome in near-complete chromosomes.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI546115; EST44588.1; -; Genomic_DNA.
DR EMBL; AUWU02000005; KAH0572596.1; -; Genomic_DNA.
DR EnsemblProtists; EST44588; EST44588; SS50377_15593.
DR VEuPathDB; GiardiaDB:SS50377_24707; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000018208; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018208}.
FT DOMAIN 1040..1486
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1660..2032
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 2311..2437
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2723..2810
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2873..3162
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 3178..3518
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3559..3778
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 4026..4140
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 4178..4327
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 4335..4672
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 3421..3469
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4677 AA; 535671 MW; 9D7A6E7C33957EAD CRC64;
MLGKSVKSLS HQKPQLTEKQ QRLLSLMADP LIHISKVPQP GQLPYHVALE RRRLALAATD
YSEAFNEFGE KLHSERAIMP LEDFDDSAFE SKTLSQFWES VTSTNDTKIL YCEFLTKTWQ
EGRITHILDD KVRVISDDGR SFKIHKIYVF IWGEDPFLHL QRLENAHFYR LQAQQTRRLQ
NYVNKMPIQG LSPFHSALRQ EIEELAKPHA TYCIVKSLAK ETQESIKTKV VDLQLPNLMD
DVGRQFLVAQ NQILFEQQLE RNPAFVSELG LQLAVEEVVR QKIVRFYNVE KSEKIYKYLI
TPSTRDSFLP SNCQFTESGE PIIDEQSLLL NVGIYLVQNF KNSRTKLNEN SLFTLKQIVK
SQAQTQNYCE ELLQTTISLD FLLKNSLNPE CYTEQQTSLF VIHKAYPTPV LPLSSKTLSL
EDFRASQFAH QRALKSRLEQ TWLGQIRNSI VQQLQDLQFE VRQSIERIQL ISQNQANASY
KNLKQPNLTK SLISFGKQFQ IEVKDRDIYD KMYLKRFLKR VQLQLEDTLR ILVSNSTDDF
CRMIEHHSKW SVKSDSTSYV ISKHEENKPY EDDGELNVCC YRAPIFNIGI IIQQVPASIE
ERNFLEKYES GYIYGVQCLD PNSKIAVDDE AEKGPEEEIV EQDQPKIQEP DDSELMIHSF
QFATNLSEFK TQLTQIYDQG IETVRSISEI ESVVLKNIIK QEKSFLASPS QDEFQFEAQR
IQIQQYCVNI VQPLNDYLKQ FSSYRDLLVL DEDKWASTIK YKAELYLREQ LETQGQTINI
PQQNLSPNMQ ASVDSATSMS PQDLRNLVYQ QMNQAKKIMS EIPDLIHVGA FIVKNTAVRH
FLASKCQRLA EHVQDIVQKI ASTKATQIGQ LYCTIQKRLQ RKCNTIEDAC KLEEFIQQKM
EKLTNSVKIN IQTMAEYHAI LDELFVQMSE NGIAQRWKTI GYPLDLKNLV NRTCQIVELD
KVKFRDQQSQ EQNSMAKNIE TLAKQVTTFA IRYKSLDEYI QASEETELMT QQLAKIQEKS
KLYNQRELLM GLQQTDYSQL DQILKDFEPQ ELLWKSVSDF RQLTHKVYNE DFKALNGNEI
ESIVDTLQRN IIKSLRSVKE NQPVVKELSE QVKKEITEFK KNVPLVKALR NPGLRRRHWL
RISEETGQFL NNLRYINGIE LQKFGDDEAS ETDYSIMSQD EINTLNKQPV NFTFKQAVDT
LHLNDMKNFE VIQRISEAAS KENTIEQVLV QLEKTWADIN FTLMEYQNSG CYILKGLDDV
IQTLDDNITM IQSMMFSPFK KFFEKSIVQW EQNLSLTSEI IEAWISVQQA WLYLEPIFSS
PDIVRQLPTE SKLFRSVDTF WRTHMAKAHK NPNVIQICTE TSKLLPNLQE NHQSLEKVQK
GLADYLETKR IAFPRFFFLS DEELLSILSN TKNPTAVQPF LRSCFENVAR IKFIEDNDYQ
MTSMTSHEGE IVQFVDPLTP SGNVESWMGQ LEKLIIRTVQ VRCQECFTKY VQAVTRDGVQ
GRALWVKSGF AQGINLVNQI AFANDTDYAI TGQYLEKYRD QLELQLDSMT EIVRTGLTKL
ESKTYSAVLT YDVFQRDQIV GLIAERVTDV SDFNWLKHPK HICNIAEFYD QPIHGVSDNY
YNGPIAAEKY QEQANNLADI SSKTENFLVS YNQVLSVLPY AYEYLGNTQR LVITPLTLKI
YTTISQSQAM FKFSACSGPA GSGKTETSKQ MTNKEFGLVC IVFNCSEGLD LIGIKRMLSG
CISTGGCLIM DEINRLSLDV LSVFAQMVLG VQRGLQMCGG STIRTPPKGK TFAEMQTVKY
VFEQAELNLM STACVIITQN PNYSGRQKLP ANLVALFRAV SVMVPNYMKI CQIRLYSYGF
KKATNLAQKA TSVFKLCSEQ LSQQSWYDYG MRAINSTIQA AGNIRQELGT LCVQENSQIP
SSINEKGDVV FDEKYYLEEQ IVLRAITEVN SPKFLQNDSQ LFYNILKDLF PGIKQPFIDY
NVLIKEVTQV LRSNIMNYLQ PDEQFVNKII DLFMTINLRH GLMTLGSAQS GKAESLYALM
HSLNRINRRE MEERIEKFIK ICKNQPTLSI SQVPSLIGED YYFQKMNIVR LNPKSITMDQ
LFGQFDVVSK EWQDGVLSTL IRNAVSDYNK HMVWYEQNLL RSSYQGGEIT FADVNPKVCV
SKNNAARQII DCCGYIDSLW IESLNTVLDD SKRLCLTSGE IICLSPVMNL VFNMDSVVEA
SPATISRCAM LYYTSLNIVS VGTTKESVGQ LVVTGTLSPD AFIQTWIDRL PDQLRLDDFD
PSTQGQITNK STFITKFNQT EKLSELALRF KELLNQFLVE SLAYIKVNCK QLQETMDANL
ITSLFRILDT FIGELKPNDF GAIEAWQIAV FMRYLEPIFF FSLIWSVGAS LADDPSRSNF
DCWLRGKISE LGYLSDCSIP MQIDDKYSSV FDFMFKYDSY DQIAEKIVQE NLDTKNLENL
VYSSSITCDW ISWSTNLKDI NLDSIMLRGI KGKNQLSQIS LSELIIPTAS NIQQSYLLRR
LVSNGYPTLV VGSTGSGKTA VIKNYLLKHE TDTKFISPLF LTFSANTQAG QVQQYLDSKV
EKRRRGIYGP PVSKKFVLFV DDLNLPMKER YGCINSHEFL RQLICHGGFY DLKEIVFKQI
IDTVQLGAMV QSGGSRNPVT QRLLRHYNII NFLELSDTIL LSIFDQIVDW WSCKSFSSFS
EEIQSPMIQM CRKVVPMGIE VYNSTRTGLL PTPAKTHYTF NLRDLSKLFQ GFLMVEPKSI
ANDINGVQLK PKQCTNNILT LFIHEAQRVF SDRLIDVNDQ KWFNQLLDKV LISKLSIATS
DILGTDRCVE DILFADFLSI GQDRLYQDVT DFNALQKILV GELNKCNEEG QQMNLVLFKS
AVHHLSRVVR ILRQSSSNIL LIGVGGVGRQ SLTRLAAYWL NCDIVTIELK KGYGISEWHE
DIKKFVMKSG LTGKQQILLL SDQHIFNDQQ LEDISILLNT CDVQAIYEPA DLATIYEEAS
ISQICMENQL PVTKPNLYDT YCARVKQNIH LVLCFSPSGT SLRNRLRKFP SLVNCCSIDY
MFNWPSDALK DVGIQIFNFN GGQEAGGLLD TSQLEFLGKF IEEQCVLNTN FTKQSIQDKI
IEFCVYVHSS IESFTQLYKE EQGRFNHVTP TLFLNLLKLF TSVLQVNYNK INSYKMQLST
GLFKLKETQE KVAQMQIDLT NLQPVLVETS ANVDNMMVQL EQDKEQADQT RQIVAREKQV
ASSKFNECDT IKKDAERDLE QAQPLLDAAL EALDKLNKND FTELGSYNNP PAAVKQCMES
VCILFSIKPK KINDPNNVGK QMEDYWDEAK KLLNASATMM TSLRTYDKSN IPADTIKKLH
KYINDPEFIP QQMQKKSLAA AGLCAFVIAM YKYYHINLQV IPKRQKLSEA QEELVIVEKS
LSETVARLTE VENKIAELED KFNKAVEQKE QLSLQVDDTA KRLDRAQTLI VSLSGEQVRW
QEQLVELDKS IKHILGDNLF GASAVIYQGA FTSDFRYRIS IDWVAKLNEL QIPTSTEKNG
NMKVTDILSD DVTIMNYINQ YKLPSDTHSM ENSSFMFTSQ KYCLLIDPEQ QAQQFLKNFY
KEQGLEVAKA SDKDLLRTLE NCIRFGKILL IINVTDEIDP SLNTVLDQNF IKDASNQICV
KLGDSAIPYN PSFKLYLCTH LANPNYSAES FVKVTVINFA ITQLGLSDQL LGVLVALERP
DQEALKASLV VSNSKMRLEL KQLSEKVLYL LSTSTGDILQ NETLIDTLSL SQKTSKEITE
KVKESEITEA EIDQTRQKYV PMSNRASILY FCVQDLVKIE FMYQYSLNWY IQLYTQSIQG
TEQCDDLETR LKNLIEAFTL YLYQNICRSL FESHKPLFAF LIALRILKSE NKITNTEMKF
LLIGSKMREA TSQNPCNDWL EEKYWKSICE LESLGSAFKG ISHSFRDLKA QIAWKDMFES
QKPEECALPS PYDTQLSEFQ RFLPISTLRP DRVLAYMRIF IEKTLGADFN KPQVFNLEKS
YKDSNNIQPI LFLLADMADP INDLMMFAEQ MRMDKKIQVL SLGRGIEKTA LNLVTTFVER
GNWCVLQNCH LSVGFLKQLQ LTLEALQADP ASVHRDFRLW LSAQPTPEFP VAILQNSVKV
SVENPNSLKA NLLRVWETNI TEKQMNEACE VPENMEKFKK LTYSLSLFYS VLLQRKKYGP
IGFNTPYPWS AADIGICIQQ LPIFLDKYPD IYPKHALQYL FAEINIGGCV TDATDQRCVS
AIVEDFLNPS IFQENWIFPT MEQKTSETPE YLLHQLTNGL GYRDYLEYIN DHVSIECHPN
NLGLNTNSNI TSDRQDSNNL LTEILILQTG KLDDAVSKEE TNTESAPVNS ETDVINSIIK
QLPDSFDLEA ISLRYPTRFE ESLNSLLVQE CGRFNVLIDT MQLNLKELVR ALRGLTILSS
ELEDIFLSVM MNKLPEAFAK YSYPSLKPLS SYLQDMNLRI SFFRNWIEIG KPGIFHISSF
FFAQGYLTSV LQNYARKYTI AIDTIGYNFE ICQATIDDIA LIENKNVLEA RIFTAGNSAF
QPDVLNDGSY ISGLYLEASR FDMELGMLVE ARPRELYSKM PIIRLIPIIV GSKEAQNTDV
DDNLYCCPCY RTLARFGTLS TTGHSTNFLL NVAVPCQSGS ARHWIKRSVA LFASLSD
//
