ID   V6LR48_9EUKA            Unreviewed;       485 AA.
AC   V6LR48;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=tRNA dihydrouridine synthase {ECO:0000313|EMBL:EST47080.1};
GN   ORFNames=SS50377_12853 {ECO:0000313|EMBL:EST47080.1}, SS50377_25937
GN   {ECO:0000313|EMBL:KAH0571746.1};
OS   Spironucleus salmonicida.
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC   Spironucleus.
OX   NCBI_TaxID=348837 {ECO:0000313|EMBL:EST47080.1};
RN   [1] {ECO:0000313|EMBL:KAH0571746.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0571746.1};
RX   PubMed=24516394;
RA   Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA   Andersson J.O.;
RT   "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT   to Fluctuating Environments.";
RL   PLoS Genet. 10:E1004053-E1004053(2014).
RN   [2] {ECO:0000313|EMBL:EST47080.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA   Andersson J.O.;
RT   "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT   to Fluctuating Environments.";
RL   PLoS Genet. 0:0-0(2014).
RN   [3] {ECO:0000313|EMBL:KAH0571746.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0571746.1};
RA   Xu F., Kurt Z., Jimenez-Gonzalez A., Astvaldsson A., Andersson J.O.,
RA   Svard S.G.;
RT   "New Spironucleus salmonicida genome in near-complete chromosomes.";
RL   Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KI546048; EST47080.1; -; Genomic_DNA.
DR   EMBL; AUWU02000006; KAH0571746.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6LR48; -.
DR   EnsemblProtists; EST47080; EST47080; SS50377_12853.
DR   VEuPathDB; GiardiaDB:SS50377_25937; -.
DR   OrthoDB; 5487726at2759; -.
DR   Proteomes; UP000018208; Unassembled WGS sequence.
DR   CDD; cd02801; DUS_like_FMN; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR035587; DUS-like_FMN-bd.
DR   PANTHER; PTHR11082; TRNA-DIHYDROURIDINE SYNTHASE; 1.
DR   PANTHER; PTHR11082:SF5; TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE; 1.
DR   Pfam; PF01207; Dus; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018208}.
FT   DOMAIN          4..238
FT                   /note="DUS-like FMN-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01207"
FT   REGION          434..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        434..449
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   485 AA;  55452 MW;  FF5A69FFC34D431E CRC64;
     MNCIAPMIDG SEYPFRQLVS HFGVTHFWTP MYNAASLLTN KPLIAQLEKT LSTEARKVVF
     QLAGTEPSAF EAAARLFMHH KNISHFELNL GCAQSCAQKG KYGSYLMTEK TLISAIFHSF
     RKLDLQISAK CRIFESDNET ADFIQFLIDE KCSRITVHAR LSKLKMGCYS GDARIQDLSI
     MLGEFQKKNP QIEFILNGGI SDFQQVKYIQ EKYKIGVMSG QILLQNCFLF CENLEAKNQF
     LVEFMKKFNP QNNYFQRIRA EFQSPRAIDY QEIPISSDWN SSLSNDKMTK LMEMQPKGAI
     FGSVELRKMR IRALLMLTEE FLSAYFGGLE APFTSIINHA MQLIGRDLLR VQTDLRALLA
     GKKWRSEFID KNEWFRMKIQ QVQCVGIEVI RRLEDGEGCF DGVEKLEGMK NSENSDRDQL
     KSGQCGAYCD QNQREQGEEK LDEMAGQQEA NRGDRLVNVS GMQNLGLEQA QQAEDDILNC
     KCDDK
//