ID   V6M195_9BACL            Unreviewed;       744 AA.
AC   V6M195;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=RNA helicase {ECO:0000313|EMBL:EST52436.1};
GN   ORFNames=T458_15785 {ECO:0000313|EMBL:EST52436.1};
OS   Brevibacillus panacihumi W25.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Brevibacillus.
OX   NCBI_TaxID=1408254 {ECO:0000313|EMBL:EST52436.1, ECO:0000313|Proteomes:UP000017973};
RN   [1] {ECO:0000313|EMBL:EST52436.1, ECO:0000313|Proteomes:UP000017973}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=W25 {ECO:0000313|EMBL:EST52436.1,
RC   ECO:0000313|Proteomes:UP000017973};
RX   PubMed=24459276;
RA   Wang X., Jin D., Zhou L., Wu L., An W., Chen Y., Zhao L.;
RT   "Draft Genome Sequence of Brevibacillus panacihumi Strain W25, a
RT   Halotolerant Hydrocarbon-Degrading Bacterium.";
RL   Genome Announc. 2:e01215-13(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034617};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EST52436.1}.
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DR   EMBL; AYJU01000017; EST52436.1; -; Genomic_DNA.
DR   RefSeq; WP_023557032.1; NZ_KI629785.1.
DR   AlphaFoldDB; V6M195; -.
DR   STRING; 1408254.T458_15785; -.
DR   PATRIC; fig|1408254.3.peg.3091; -.
DR   eggNOG; COG3973; Bacteria.
DR   HOGENOM; CLU_010312_4_0_9; -.
DR   OrthoDB; 9787585at2; -.
DR   Proteomes; UP000017973; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.160; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   InterPro; IPR027785; UvrD-like_helicase_C.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13538; UvrD_C_2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000017973}.
FT   DOMAIN          192..575
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          10..37
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         213..220
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   744 AA;  85708 MW;  BED35A14D60D32D9 CRC64;
     MRHPDYEHEQ KKLEETIDLI DHEISSLRED IREATDDYVK QVVNFSKAKE LRYLEEHGRE
     KPYFGRVDFI KDEVYERDSV YIGKRGVVRS DTFDSIVVDW RAPIASLYYS GESKDAFYRM
     GREIVRGEVT LKRNFAIENG KITGIYDGAV KETINREMSH PDDFLQEGFI DEFLAANLNE
     TNDSRLKDIV ATIQSEQNDI IRAEKERPIV VQGVAGSGKT TIALHRLSYL IYNYQDSMQS
     KKFMVFAPNR MFLTYISEVL PELGVDDVMQ STFVDWAAKL VKPMLPKGWR ITSPDKPLAL
     FFDDEQEPRE QEVASNRLRF KGSLACKQAL EQYIHYIMDT RIPFKKLSFV FSRTKQVFAI
     EGSFIKKSFM ELFSHLPYHR RVDALRKHLK QEMNKHFYAH LRELKIDLDK QGLAKYEKML
     DQILDTYMVS FPRLDVFASY RELMSEPSLL RRLAPTEISD DVIEDTCSSS HALFAQERIE
     VEDIAALLYL HHLVEGMDGA GQFDHTVIDE AQDLSALEIA VIALATKANS LTIVGDIAQG
     IHAYRGIHSW DELTQGVFLQ PRASMYTLSQ SYRSTVEIMR CANEILKQID LPITVLAKPV
     LRYGERPEML LQSSRNDMWE QIASRVKQYM DEGFRSIAIV TKTIAGSKRA HKSLKAQIPS
     LTLLSSKDKH FPGGITVMPA FLTKGLQFDV VILVDVEQYE RNEWDAKLLY VAMTRPVHRL
     VVTGNPDQPG QLWIRMPQEL YTTT
//