ID V6M597_9EUKA Unreviewed; 2502 AA.
AC V6M597;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 13-SEP-2023, entry version 35.
DE SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:EST48529.1};
DE SubName: Full=Outer-arm dynein beta {ECO:0000313|EMBL:KAH0573612.1};
GN ORFNames=SS50377_11139 {ECO:0000313|EMBL:EST48529.1}, SS50377_23547
GN {ECO:0000313|EMBL:KAH0573612.1};
OS Spironucleus salmonicida.
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Hexamitinae;
OC Spironucleus.
OX NCBI_TaxID=348837 {ECO:0000313|EMBL:EST48529.1};
RN [1] {ECO:0000313|EMBL:KAH0573612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0573612.1};
RX PubMed=24516394;
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 10:E1004053-E1004053(2014).
RN [2] {ECO:0000313|EMBL:EST48529.1}
RP NUCLEOTIDE SEQUENCE.
RA Xu F., Jerlstrom-Hultqvist J., Einarsson E., Astvaldsson A., Svard S.G.,
RA Andersson J.O.;
RT "The Genome of Spironucleus salmonicida Highlights a Fish Pathogen Adapted
RT to Fluctuating Environments.";
RL PLoS Genet. 0:0-0(2014).
RN [3] {ECO:0000313|EMBL:KAH0573612.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 50377 {ECO:0000313|EMBL:KAH0573612.1};
RA Xu F., Kurt Z., Jimenez-Gonzalez A., Astvaldsson A., Andersson J.O.,
RA Svard S.G.;
RT "New Spironucleus salmonicida genome in near-complete chromosomes.";
RL Submitted (DEC-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI545981; EST48529.1; -; Genomic_DNA.
DR EMBL; AUWU02000004; KAH0573612.1; -; Genomic_DNA.
DR EnsemblProtists; EST48529; EST48529; SS50377_11139.
DR VEuPathDB; GiardiaDB:SS50377_23547; -.
DR OrthoDB; 312149at2759; -.
DR Proteomes; UP000018208; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018208}.
FT DOMAIN 10..104
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 265..412
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 634..721
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 795..1062
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1077..1414
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 1444..1665
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 1909..2030
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2062..2198
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 2205..2498
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT COILED 1299..1382
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2502 AA; 285748 MW; C73E7A4675820681 CRC64;
MSFNLEEIVK EEEKVICRAL RDSNNPKIVK EDMAIFTGLI EDLFPGVRID RLIDPTFEKM
IAESCKDRGL QPEQSFMIKV VQFEELLQIR HSIFILGFAA VGKTSVWKVL GDTYKKQGKK
FVHHVINPKA VTTKELYGYI QPATREWKDG ILSTIMRSMA ELPDTPQMPK FFVLDGDIDA
LWIESMNTVM DDNKILTLAS NERIPLRPSM RMIFEIGSLK YASPATVSRA GIIYVNESDV
GWPFYFQSWI EKLESSLERS TITVFQQKYV QPCLEEIKRN YKTIVPINDM TTVQTITRLM
TSLLDDYNKS PAAKVNLAAN MANQQAQQSG QSNQMPDYSK DVIEYFFIFA VVWSIGGVLF
KDQLNNDFRK NFSKFWRPAF PKGIVFPAQG DIFDYFVEVN AETGQPDWKL WSSQVSPYDH
DAEQAVNNIH VETIDSYRIH YIMDNLLRNG HPILLAGPAG LGKSVLLKSK LKKLNDQQWQ
FATISMNYYT TSAQIQMVLE TYIEKKVGNK FAPLGTRKLI YMIDDLNMSK VDEYGTQQPI
ALLRQHIDYG FWYDRDKLVT KEVSSVQFVA SMNPYAGSFE IDPQYQWHYS PFSVDVPSEE
NLLQIYSSIL NAHMNREGVN FKKELQQCAT ATIKTLLKIH SKVSQEFLPT SIKFHYQFNL
RDLTNIVAGI MKVKPDHFKE GPVNLVQLLL HECERVYCDR MCEQDDKEKY EKLVQDLVKQ
ELSTVTAIDT TRPKSAASTQ ININMDQVFS PEANYFSNFA LGIGEGSYAP LQKYDRMNQL
LNEALLSHNE SNAEMNLVLF KDAMQHVCRI SRIIKTSDAL LVGVGGSGKQ SLARLAAFIN
EYEVFSITIS STYGVADFKA DLRKLYRKAG EKDIPTMFLF TDQQITNEEF LVYINDLLSS
GFIAGLWPAE EEEEVINNMR NRVKDAGIPD TKENVMQFFI QKVKENLHVV LGFSPNGDAF
RVRARKFPSI VNCTTIDWFM PWPYEALESV AFNFIKNRDK TKEKKYDDVI VDLSDEQCLA
LAKFMAKANE LVNTLSEKYK RLEKRYAYTT PKSFLELISL YLRQLYSRTQ QIQNSINRLE
NGNATLIKTE QDVGELKTRL EDQKVEVKIQ QDAVAAMIGG ITAEREKVGA KAADAEIEKS
KTALVEADVN KAANEANKEL EKAKPIQEEA ERALNTLNKD NLTELKSFAN PSSEVARVME
AVIIMLNKPG VVPRDLSWKA AKSLMANVDK FLKQLQEFDK ENINNANKQA VLKYTKDENF
TGEYIKSKSG AAAGICDWVR NIIKFHDVFL FVEPLRQNTM ELQVSLDGAQ KRLKQVETQV
NLLNESLGKL EAEFKAAEDK RDAVLKDADD MEKRLELANR LVNGLASEKV RWRQSVENLK
QRNNTLLGDV LIIAAFISYS GAFSRNYRTE MMDGWMILIK ELNIPIQEEF DPLSLLTDPA
VIAQWNNDKL PTDRFSLENA SIFSNCDRWP LIIDPQLQGM EWIKTREAKN NLKVIRLNQK
DWLNVVKDAV ENGYPVLVEN IAETIDAVLN PILGREIVNK GKANQAIRIG DKEIPYHNDF
KIFFQTKYPN PHYSPEIQAQ TTLINFTVTE EGLEDQLLAD VVLEERPDLE ELKTKLMREQ
NEYAITLQQL ESDLLERLSK AGDNIIEDIG LITNLEKTKA TSTEIAIKVQ EAKETEVNIN
KAREEYRPVA SRSSMLYFLL NSLAVIDHFY QFSLSAFKVV FFRSIRESEK SEEVQQRVLI
LLDSITYGIY CYTTRGLFER HKLIFNSQLC FNILRKANQL PNAEFQFLLR GTQAVGRDNT
LGEFISNSSW GCILALAQNI PDVFAKLPDD IEGSAKRWKE WVQHETPEKE KLPQDWKSKT
QLQQLCIIRA LRPDRLLTSM SQFIANSIES KYIEAVPFNF PETFKTSSKT EPIFFVLSPG
VDPVKDVELL GKKLGFSFDN GLIKSVSLGQ GQEKNAERFV EEMSQKGGWV LLQNIHLMKN
WQVRLEKLMD QICQPTAHDN FRCMISAEPN PNPTIAAVLP GIVQMCIKVT NEPPTGIKAN
MNRAIALFNN DVFESCSKAN EFKSILFSLT FFHAILLERR KFGSIGWNTP YNFTNGDLTI
CKDVLFNYLE ANVKVPWDDL KYMFTDIFYG GHIGDNLDRR FIKAYANEIF SDALFEDGKA
LAPDFFAPPP MTFDGYKQYF NETLPPDNPK MFGLHPNAEI TYLTSQSNTL FAMLMQMQPS
DAAAVGEGGE EKDFKDRIEE LIQLIPEQYN VGDLMERNPD ALPYNSVCIQ ECARMNALTN
QMKLTLTDVK LGLNGELTIS EQMEKIIDAV RLEIVPTIWN KVSYPSLKGL APWLKDLEHR
AKQLSDWSAE LGLPKCVWLS GLFNPQSFLR SVMQTTARVN QWPLDMMDLN VEITKKELSD
ITAAPREGAY ITGLFMEGAR WDKKSSSIRD AILKDLYPQL PPIYLKAVTN DKIEIKDTYE
CPTYMTKQRN GLTYVWSFNV KTREPSSKWI LAGVAMLLAN DV
//
