ID   V6TW49_GIAIN            Unreviewed;      1118 AA.
AC   V6TW49;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=AAA family ATPase {ECO:0000313|EMBL:ESU42819.1};
GN   ORFNames=GSB_94322 {ECO:0000313|EMBL:ESU42819.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU42819.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU42819.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU42819.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU42819.1}.
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DR   EMBL; AHHH01000069; ESU42819.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6TW49; -.
DR   EnsemblProtists; ESU42819; ESU42819; GSB_94322.
DR   VEuPathDB; GiardiaDB:DHA2_94322; -.
DR   VEuPathDB; GiardiaDB:GL50581_3311; -.
DR   VEuPathDB; GiardiaDB:GL50803_0094322; -.
DR   VEuPathDB; GiardiaDB:QR46_2363; -.
DR   eggNOG; KOG0740; Eukaryota.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR14690:SF0; IQ AND AAA DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR14690; UNCHARACTERIZED; 1.
DR   Pfam; PF00004; AAA; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   4: Predicted;
FT   DOMAIN          780..957
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          497..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          611..654
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          858..884
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        619..639
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1118 AA;  123608 MW;  5C0C42DD3C87BF40 CRC64;
     MSDRQWREAM TLLMEQINKE STSDPRVIRL QNSQLLQQQL NWYNTYRHVY TLLEECYDQL
     RHPQKRRVIK KSLDATIGRM LESRRNICCL TGTWSPDVFS LMNNRTLLPK DIELYVPRFL
     VSDNFSLSRR NDLLRLLLER YELLSQNGSC FDMTHSLRGY IPGKGIVEEE AETQMQRAMS
     LEDAILLIQR AERGRAARLR AKLVQDIMKV KPAGRQIQGG RVHSREQASV IIQKYWRRAL
     AKSKVNAMKQ ADLVFLGLAV SSAAQGVGSS ILPIVQDMVS SECIKREKQY EADYLARLNA
     RKDVLDKSIL SIGKPGIPDS GIAASSNLNT TLTPLTSVIA ATTCDGMEST YALSRYIDKS
     NILSNQPYMT QVTNAYDSGL PLMHDLVRSR ILLADAKKLG QSAYQAELIA KRNVALRIQA
     ELAMQSAEDV ILQELKEKEG TELERVLYSR HKKAIAQFRD LNDGAIPTSA LDIASPDEKL
     VMEKVAAERE AELLRRGLKG KKKKGKKGSK GSKSTKAAAS KAATDEVVED PDKAKVSFLS
     AYLHDIVDTT VEYFNRWQRH DPANLAEQPY DIEYLKESLR PQILKDVYDS VAETINAELD
     NMRTITDATK QLVESKKGGK GKKGKKGSKG KKGKKGKKGS KIPPTLEPPP PVGPVGDATV
     EAAYAELVSE GLIKAIKPAR MRDFVGCDTY IAPSSQETEF MQRIAVKALQ KFTQQGTIAI
     DKKAAGIVDP VEQEKLAAAK ASVPAYALLP DLPSYNQIKQ DIIANVIIPL GCPMARAVPH
     SNTLLIYGAP GVGKTLLSRI IATETGALVI DVSPANIVNK FPGQEIGVIF KLIKVVIASN
     QPAIIYFDEA ELVLADTKEK KGKKGSKGNK GSKTKGKSKL PGDDAETPGY SMCCEGYPKL
     SDPDYNPYRL RKELLSLLKS INEYDGVLVL GCATRTMTRE KAIADFFQRH IYVPLPDYNT
     RLKLISHFFN KMGLEQFALM GVAKDVPIGQ YSSSKLSTGA FDSRRFTALG LMNLTSGIAI
     TNNETEKIPF DLNSFAKVTE GFTAGQIQQA LHMVCTPGRV ASLGSKPLSV VEFGQVLSHL
     QPQYDSQVAH VALYKMNKAP PEYQPPIPLA DPAPKKGK
//