ID V6TYI7_GIAIN Unreviewed; 1579 AA.
AC V6TYI7;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 28-JUN-2023, entry version 31.
DE SubName: Full=Structural maintenance chromosome protein, ATP-binding cassette domain {ECO:0000313|EMBL:ESU44018.1};
GN ORFNames=GSB_150684 {ECO:0000313|EMBL:ESU44018.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU44018.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU44018.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU44018.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU44018.1}.
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DR EMBL; AHHH01000031; ESU44018.1; -; Genomic_DNA.
DR EnsemblProtists; ESU44018; ESU44018; GSB_150684.
DR VEuPathDB; GiardiaDB:DHA2_152693; -.
DR VEuPathDB; GiardiaDB:GL50581_4144; -.
DR VEuPathDB; GiardiaDB:GL50803_0023185; -.
DR VEuPathDB; GiardiaDB:QR46_1531; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ESU44018.1};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Nucleotide-binding {ECO:0000313|EMBL:ESU44018.1}.
FT DOMAIN 9..1562
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT DOMAIN 786..882
FT /note="SMC hinge"
FT /evidence="ECO:0000259|Pfam:PF06470"
FT REGION 1272..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 267..331
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1092..1198
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1579 AA; 175084 MW; 19EC7A098B3342A7 CRC64;
MILPALDMYI QEIILDGFKS YATQTRIGPF DPSFTAITGL NGTGKSNVLD AICFVLGISS
LSRIRVTSLT ELIYKQGQAG VTKASATLVL NNEDPKQSPP GYESYHMLEI SRQIFKNGTT
KYLLNGAVSK LKVIKHLFRS AGLNVDNPTF LVLQGRITTI LSMKPMELLG LVEECAGTTI
YDTNRSEAVK IFSAKESKLQ EVSDTLTLDI FPRLQKLDAE RQAAVELGRL ENAMKIMGLL
TDAHRLHAIT IQFLSVCQKK QTQQTRIQEM VQESKAVEEH ARELVEAIRS LDIEAQGVET
SAQLEKLTSE YSNAKSEMEV LAERVRAMRS QEMALRKAMF EKENLYRMTK EKISSIQQKL
QRIGSNPEVK RLAEQLDQIL TEQKLTEARL MLATSGSLLK ASVKRDFLKI SVPLTIEDAL
ISTGPALLEF QKNIQALLSS SYHSPDTTDL YNILWTKLTQ TLQNQGHTIL EHFIDDSAEW
VFSLRSADSL TPVEIVSNLS LLLSKISVDV EPQLGSFISA HKKIEFSSTA GLKIAAETDE
ANMGTLLQKI QELFGHLRKV LTQLTELSAI FSSIGQPVTE QHGSAALQSG QTELYALIAN
PKTGLIDMDQ FSIMHRLINE LTELLQMDHP TLVSKMSNAT RILFTMLHAH IMQGQDIDAG
ALDMSALRYL DTLDETIKPL RLLAVRFFDL LAQRAATFAS HVDAVLMDVS PDTYFNAILQ
SCSGSASFST VAYMIASLSL DTRLVYDLIG PTLGFFTINT RQIEEYCRAT CGVVDRQRYC
QVIRILEMVA LPKLFHIVFT SAEKAMRFIR NKEICTERIT AVPLDKIGKK GTGSHHEVRD
TLAKERAFFL TDFISSINST VSDYVFGKTV LCENTTSARR IAYSSSLGFR CITFDGDIVS
PSGSVSGGTR SFDLSSTANV FSATDAYRRN GGAHVLLTPV KGTGAEFIDS AASSLYYDFI
AMEKSTSSQA REIYSAVNKI VDAAKLSLYG VHKCGDEVSS SIASSLQSLQ SRLPVSILTM
LSENRITNIP IPCQLTVLLE LQGDHNKYNE SILRISESAG KVILLDRIMA EMKTLISDTS
GSDDPASLRD KLKSYAKQAA QLEAQVLHLT EQHNKKSLET DLVANEEEVR SLQTVIKEST
EELKRMEDAL STVTKTLDRQ TERVEAAHMR LREQSKHLEG LVDEKLNKEI EYKTLQSRLK
EIDAHISAES EALTVTKEAS LRMCREHESL IDKLSTTLNT VCALLMRGTN YVQCVTDLQK
YDVGQISTLD GTRRATGRNH KGQRSHRGAE SDGDLIFLSP ELLQILDSLQ NDNPTQPGVD
YDELTKSITS CPFIMDGIAQ RMQSQREQEG GRDPVQFLLN NPGVFEDLQA HLKSVHSKLV
LSAGVSAGAQ STYEELRTNA MELQRLRDKI MKDKEKIMTF ISQIDDKKMD ALKASYERVN
SDLSKVFAVL LPGSQASLRM MDSNDLSKGV FFDVKLGATS TTISCLSGGQ RSLLALSLIF
SLLLYKPCPL YILDEIDAAL DLNHTHNIGI LIKKSFPQSQ FIVVSLKDGL FSNANVLLKT
KFVGGSSAVD RYARNADSA
//
