ID V6U1X2_GIAIN Unreviewed; 459 AA.
AC V6U1X2;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=tRNA-dihydrouridine(16/17) synthase (NAD(P)(+)) {ECO:0000313|EMBL:ESU43230.1};
GN ORFNames=GSB_152917 {ECO:0000313|EMBL:ESU43230.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU43230.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU43230.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU43230.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU43230.1}.
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DR EMBL; AHHH01000055; ESU43230.1; -; Genomic_DNA.
DR AlphaFoldDB; V6U1X2; -.
DR EnsemblProtists; ESU43230; ESU43230; GSB_152917.
DR VEuPathDB; GiardiaDB:DHA2_152532; -.
DR VEuPathDB; GiardiaDB:GL50581_2333; -.
DR VEuPathDB; GiardiaDB:GL50803_005213; -.
DR VEuPathDB; GiardiaDB:QR46_2449; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR PANTHER; PTHR11082; TRNA-DIHYDROURIDINE SYNTHASE; 1.
DR PANTHER; PTHR11082:SF5; TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE; 1.
DR Pfam; PF01207; Dus; 1.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE 4: Predicted;
FT DOMAIN 21..309
FT /note="DUS-like FMN-binding"
FT /evidence="ECO:0000259|Pfam:PF01207"
SQ SEQUENCE 459 AA; 50611 MW; 7D8B0363BF2923B4 CRC64;
MQQHPGGPEW YVQLGSPSKG IAPMVDGSEL PYRLLTRRYG VELAWTPMYN TNNLVTSSKA
MNQLVAELKY GGSIDRPLVL QLSGNNPSNF EIAYNTLIQM GAGHCFDVVE LNMGCPQAVA
LRGKYGAYLM GHLSLAEEIL KILVAVTTLS GLGHKVAVKT RLDTSVADTV AMCLRLCSTG
VAMLTLHGRT KVQRTGSAVG PPDWQALASV FKDLRAAYPQ MVFFANGGVW NIETHERLCT
FTGCHGTMSA SMLTENAGVY TCRDRLNRKS STIADLAHAI GEHWIDQAEM QKRFVTARSL
RKCIYTTSKA VEEYPLDAPM YADLIREWIV SPQKDEDAVI TIQLAEASLE QRQIRVTLAL
EYLLIARSVP IFVTASQLIS HVMRLIGRDL AAANVDLRQT ITVRSKEQIR DTPSGEQEGA
NSMVQMCNIL LEAVCELYYR LNANVCCIIS SELSQDADL
//
