ID V6U398_GIAIN Unreviewed; 583 AA.
AC V6U398;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Sodium-driven multidrug efflux pump {ECO:0000313|EMBL:ESU45481.1};
GN ORFNames=GSB_17326 {ECO:0000313|EMBL:ESU45481.1};
OS Giardia intestinalis (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU45481.1, ECO:0000313|Proteomes:UP000018040};
RN [1] {ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA Nash T.;
RT "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT Pig).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESU45481.1, ECO:0000313|Proteomes:UP000018040}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GS {ECO:0000313|EMBL:ESU45481.1,
RC ECO:0000313|Proteomes:UP000018040};
RX PubMed=24307482; DOI=10.1093/gbe/evt197;
RA Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA Nash T.E.;
RT "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT Pig).";
RL Genome Biol. Evol. 5:2498-2511(2013).
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESU45481.1}.
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DR EMBL; AHHH01000005; ESU45481.1; -; Genomic_DNA.
DR AlphaFoldDB; V6U398; -.
DR EnsemblProtists; ESU45481; ESU45481; GSB_17326.
DR VEuPathDB; GiardiaDB:DHA2_17326; -.
DR VEuPathDB; GiardiaDB:GL50581_4461; -.
DR VEuPathDB; GiardiaDB:GL50803_0017326; -.
DR VEuPathDB; GiardiaDB:QR46_0320; -.
DR Proteomes; UP000018040; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002528; MATE_fam.
DR PANTHER; PTHR43549; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR PANTHER; PTHR43549:SF2; MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 105..131
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 478..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 539..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 62869 MW; 1A95E8CC02FB731B CRC64;
MSTPVVDISP NGPAPSSLAA AGGSEMCLSQ EQLGSPTIAT KVLTQVRPQT GYDNSSELVP
TVSIPGFSEY NYNGSPSNAN LVPCVEINEE DTIEYKRLCA RSPCITLLSL SLGPLLSNIF
TSIVSIVLSV YVSKALSNPN AAVAALTIAA VPEFIANSIA WAMLIGSSAT VSSSLGKGDI
VGAQTAAING VTMALIFGIL MLVIMLPSAR QILLSLASSE HSSEIISIAY DYIFVFICGI
PVTALNFTLN GVMSGTGNVK LVSTCNIIDI VLTLGVFAPI FLFVPATKAS LGVRGASLAI
VLSRAIVLCV YLYVYIFRGT VRMNWKLLHQ NRTFAYVKAI LGVGCIDLIS SLSGTVILGI
VSTFVSKLAT DYANLNSSGN EKQTYEEVMA SWACLNRIYN LVVAISFGVT GGYLAPASYA
YGRKMYARFI SLTWSCFIYD SVLLLSLGVL FIIIIPWFSQ IFSTSKLYTE MSTQIVRIML
ATSAILPFQF IITTICQACN MILIGLIVGV ATQVAILPTC FVIIYHVSLK YIPENVWLRY
RLCILSFTFN DILSGIISIG VWIYPMRKFK KLVQEQKAES GKS
//
