ID   V6U462_GIAIN            Unreviewed;       702 AA.
AC   V6U462;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN   ORFNames=GSB_112811 {ECO:0000313|EMBL:ESU45407.1};
OS   Giardia intestinalis (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=5741 {ECO:0000313|EMBL:ESU45407.1, ECO:0000313|Proteomes:UP000018040};
RN   [1] {ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=GS {ECO:0000313|Proteomes:UP000018040};
RA   Adam R., Dahlstrom E., Martens C., Bruno D., Barbian K., Porcella S.F.,
RA   Nash T.;
RT   "Genome sequencing of Giardia lamblia Genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of Genotypes A1 and E (WB and
RT   Pig).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESU45407.1, ECO:0000313|Proteomes:UP000018040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS {ECO:0000313|EMBL:ESU45407.1,
RC   ECO:0000313|Proteomes:UP000018040};
RX   PubMed=24307482; DOI=10.1093/gbe/evt197;
RA   Adam R.D., Dahlstrom E.W., Martens C.A., Bruno D.P., Barbian K.D.,
RA   Ricklefs S.M., Hernandez M.M., Narla N.P., Patel R.B., Porcella S.F.,
RA   Nash T.E.;
RT   "Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and
RT   GS) and comparative analysis with the genomes of genotypes A1 and E (WB and
RT   Pig).";
RL   Genome Biol. Evol. 5:2498-2511(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ESU45407.1}.
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DR   EMBL; AHHH01000006; ESU45407.1; -; Genomic_DNA.
DR   AlphaFoldDB; V6U462; -.
DR   EnsemblProtists; ESU45407; ESU45407; GSB_112811.
DR   VEuPathDB; GiardiaDB:DHA2_112811; -.
DR   VEuPathDB; GiardiaDB:GL50581_404; -.
DR   VEuPathDB; GiardiaDB:GL50803_00112811; -.
DR   VEuPathDB; GiardiaDB:QR46_0504; -.
DR   Proteomes; UP000018040; Unassembled WGS sequence.
DR   InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR   InterPro; IPR030564; Myotubularin_fam.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR   PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR   Pfam; PF06602; Myotub-related; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE   4: Predicted;
FT   DOMAIN          266..702
FT                   /note="Myotubularin phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS51339"
SQ   SEQUENCE   702 AA;  78921 MW;  66672AB17819FDDB CRC64;
     MRRNEVFLTQ LDNGVVSKVP GSFSRFWHEL VGDFPPFTKV VTAKESSFSC SIITTSHRII
     ITQQLQPGLI ATISKADNQG QLPICASIPF SHFSSVLSSG VSTTGVTVTF NFYYPLQLNL
     FVPVGQNPQA VVDQTVKHWC IQVRGVFLRP MSIPLINAAK DMKGVGQYAD IVTFCDNRPT
     FLRSADDSKG NDRWTHYSIS RTLLAMQKSG GTLRATLAMG PDQSPEALVE PLVIHRYLNI
     KAHYNSALDL GDSPVYIKAS IDSLLGGEVE ALKELLEYTP EGDQGSTVDP VQTHLHICVN
     KDYQVCETYP YLLLLPNQAI IRPNTFVDNR FLCVAGFIDG LPIFRSGNPI LGIGANPIAD
     FLDFYMPSTR YKRAIVFSLG PTTYYDIQKP VSTMPPNSNG IFIDYANYLR VLQTKLPFPE
     ELAMAFNTMW SLNLVQPTQF FSSELPVNWN LQQKGEADLY SVAADLFDTF HIKTIKEDND
     FQYTVRVEES GWLDYVISFV ATARLLVELL RDDNCQNMII LSGDLEVFWT PVILILSTII
     ANKRYRTING LLELMRQYLP SFGLPIASCM NFEGSQLEAK APIQEQHYRL ITQRAGHVPI
     IPILMDCISL LVHYSRPAFG FGEGFLMHLS AIIYSNLYGD FLFDSEAERY FLAVPELTDS
     LYSQETIELL CKRFETPIVV DSLELSSWPT ISKFWSLGLD FS
//