ID V7AQY9_PHAVU Unreviewed; 2033 AA.
AC V7AQY9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=PHAVU_009G009000g {ECO:0000313|EMBL:ESW07984.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW07984.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; CM002296; ESW07984.1; -; Genomic_DNA.
DR RefSeq; XP_007135990.1; XM_007135928.1.
DR STRING; 3885.V7AQY9; -.
DR EnsemblPlants; ESW07984; ESW07984; PHAVU_009G009000g.
DR GeneID; 18618756; -.
DR Gramene; ESW07984; ESW07984; PHAVU_009G009000g.
DR KEGG; pvu:PHAVU_009G009000g; -.
DR eggNOG; KOG0902; Eukaryota.
DR OMA; MSQRDEN; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000000226; Chromosome 9.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1488..1665
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1739..2017
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 205..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1410..1430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2033 AA; 223764 MW; AB36F8EF189694FF CRC64;
MEALIELCDL IAQNPTQFSE KLSWICSKCP PPEYLSAGSP RVSRSQLNAV LAVSRFLSKC
PDSADLRPKS VVVEFLRAVP HSFTQSFWPH PFNADSVASF FLDFTGYVSK AAQESPDFTD
ELTAFSGEVI ISAIGEPRSS IARAFLAGVA QNYVPISSSD ANKLVTCLID QFSTHIAVVP
STPKELAIAE NSSSQSSPLS VNHQALANYN DSPGNENTSG SSSSVASKAA DDASTASSRG
VVNGPHHVYR SSADQLALNL GLNDGTLGPV SSSQQVASFE EESVEFLERQ EIAFKLIAHV
LQNVPIESGL LEQVRLIGKK QIQSMSVFLK IRKRDWHEQG SLLKARINTK LSVYKAAVNL
KIKSLSALDS DSRSVKRLVY EAVAILIDAA EACLLSGWRK LRSCEELFDS LLLGVGQIAI
ARGGQPLRIL LIRLKPIVLN VCAQPDTWSN NQGTMFESVT KASCRIIESC WNKERAPVDT
YIMGLATSIR ERNDYEEQDN QEKSAVPFVQ LNVIRLFAEL SVAVNKSELV DVILPLFIES
LEEGDASTPS LLRLRLLDAV ARMASLGFDK SYRETVVLMT RSYLNKLSNV GSAESKTEAA
EATTERVETL PAGFLVIASG LTGDRLRSDF RHRVLSLCSD VGLAAEAKSG RSGADFLGPL
LPAVAAICSD FDPTLNAEPS LLKLFRNLWF YIALFGLAPP IQKTPGTAKA VSTTLNSVGS
TGAISLQAVN GPYMWNVEWS SAVQGISQGT PPLVVSSVKW LEDELELNAL HNPGSRQGSG
NEKAALSQRA ALSAALGGRV DVTAMTTISG VKATYLLAVA FLEIIRFSSN GGILNGGTTF
DAARSAFTCV FEYLKTPNLM PAVFQCLTAI VHRAFETAVL WLEDQVSEIG HEAETRDSIL
TMHTCFLIKS LSQREDHIRD IAENLLTQLR DKFPQVLWYS SCIDSMLFSF NDDSSTSIIN
DPAWTATVRT LYQRIVREWI IKSLSSSPCT SQGLLQDKLC KANTWQRAQP TIDVVVLLSE
IRIGTGKNDW PIQTANIPAV MAAAAAASGA NLKASESFNL DVISSGKCNQ AAATVKCNHA
GEIAGMRRLY NSIGGFQSST APPGLGLGAG LQRIISGAFP QHPQAEDDSF NGMLLNKFVR
LLQQFVNIAE KGGEVVRSEF RDTCSQATVL LLSNLSSGSK ANMEGFSQLL RLLCWCPAYI
STHDAMETGV FIWTWLVSAA PELGALVLAE LVDAWLWTLD TKRGLFASET RFSGPAAKLR
PHLSPGEPEL QPEINPVEQI IAHRLWLGFL IDRFEVVRHQ SVEQLLLLGR MLQGTTKLPW
NFSHHPAATG TFFTLMLLGL KYCSCQFQGN LQKFHLGLQL LEDRIYRASL GWFAFEPEWY
DTNYANFAQC EAQSVSLFVQ HLSNMKGDSV QVGSKGNGQE NGNSLTDTSD HYHPVWGQME
NYALGREKRR QLLLMLCQYE ADRLDVWAQP TNTKESSSRP KISADKWVEY TRTAFSVDPR
IALSLASRFP TNTFVKTEVT QLVQANIVDV RNIPEALPFF ITPKAVDDNS VLLQQLPHWA
PCSITQALEF LTPAYKGHPR VMAYVLRVLE SYPPERVTFF MPQLVQSLRH DDGKLVEGYL
LRAAQRSDIF AHILIWHLQG ETVPEAGKEP SSGKNGSFLE LLPAVRQLII DGFNAKARDI
FKREFDFFDK VTSISGVLYP LPKEERRAGI RRELEKIEMD GEDLYLPTAP NKLVTGIRVD
SGIPLQSAAK VPIMITFNVV DRDGDRNDVK PQACIFKVGD DCRQDVLALQ VISLLSDIFE
AVGINLYLYP YGVLPTGPER GIIEVVPNSR SRSQMGETTD GGLFEIFQQD FGPVGSASFE
AARQNFIISS AGYAVASLLL QPKDRHNGNL LFDNVGRLVH IDFGFILETS PGGNMRFESA
HFKLSHEMTQ LLDPSGVMKS DTWSQFLSLC VKGYLAARRR MDGIITTVAL MLDSGLPCFS
RGDPIGNLRK RFHPEMSERE AANFMTHVCK DAYNKWTTAG YDLIQYLQQG IEK
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