ID   V7BT94_PHAVU            Unreviewed;       633 AA.
AC   V7BT94;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
DE   Flags: Fragment;
GN   ORFNames=PHAVU_006G1942000g {ECO:0000313|EMBL:ESW20265.1};
OS   Phaseolus vulgaris (Kidney bean) (French bean).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX   NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW20265.1, ECO:0000313|Proteomes:UP000000226};
RN   [1] {ECO:0000313|Proteomes:UP000000226}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX   PubMed=24908249; DOI=10.1038/ng.3008;
RA   Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA   Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA   Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA   Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA   Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA   Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA   Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT   "A reference genome for common bean and genome-wide analysis of dual
RT   domestications.";
RL   Nat. Genet. 46:707-713(2014).
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
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DR   EMBL; CM002293; ESW20265.1; -; Genomic_DNA.
DR   RefSeq; XP_007148271.1; XM_007148209.1.
DR   AlphaFoldDB; V7BT94; -.
DR   EnsemblPlants; ESW20265; ESW20265; PHAVU_006G1942000g.
DR   GeneID; 18629314; -.
DR   Gramene; ESW20265; ESW20265; PHAVU_006G1942000g.
DR   eggNOG; KOG0497; Eukaryota.
DR   OMA; NCFLNYV; -.
DR   OrthoDB; 608at2759; -.
DR   Proteomes; UP000000226; Chromosome 6.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0042300; F:beta-amyrin synthase activity; IEA:UniProt.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF58; BETA-AMYRIN SYNTHASE-RELATED; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|RuleBase:RU362003};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          15..272
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          289..623
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ESW20265.1"
SQ   SEQUENCE   633 AA;  72667 MW;  FDE56BD4FDE1EF7F CRC64;
     VICLYITGHL DSVFSEEHRK EILRYTYCHQ NEDGGWGLHI ESHSTMFCTA LNYICMRILG
     EGPNGGHNNA CVKARNWIHD HGGVTYIPSW GKFWLSVLGV VDWCGSNPMP PEFWILPSFL
     PMHPGKMWCY CRLVYMPMSY LYGKKFMAPI TPLIANLREE LFVQPYDKNT WKKARHKCAK
     EDLYYPHHWI QDLIWDSLYV FTEPLLNRWP LNKLVREKAL QVTMNHIHYE DENSRYIAIG
     CVEKVLCMLA CWVEDPNGDA FKKHLARIPD CLWISEDGMT MQGIGTQSWD AGFIVQALLA
     TNLIDEFGPT LAKAHDFIKK SQVTENPSGD FKSMYRHICK GSWTLADRDQ AWQVSDTTAE
     CFKCCLLLSV LPEEIVGEKM EPEKLYDSVN LILSLQSANG GMSAWEPARA QEWLELLNPT
     EFFADIVVEH EYVECTASAI QVLVLFKKLY PEHRKEEIEN FIAKAVPFIE DSQLDDGSWY
     GKWAVCFTYC SWFAIGGLVA AGKSYKNCVA IRKAVEFLLR IQTEDGGWGE SYLSCPRKEY
     VPLEGGRSNL VQTSWALMAL ILAQQAERDS TPLHRAAKLL INSQLEDGDW PQQETLGVYL
     RNCLVHYPFY RNVFPMWALA EYHKNVLLPS VTV
//