ID V7CQU9_PHAVU Unreviewed; 478 AA.
AC V7CQU9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=PHAVU_001G000700g {ECO:0000313|EMBL:ESW32587.1};
OS Phaseolus vulgaris (Kidney bean) (French bean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Phaseolus.
OX NCBI_TaxID=3885 {ECO:0000313|EMBL:ESW32587.1, ECO:0000313|Proteomes:UP000000226};
RN [1] {ECO:0000313|Proteomes:UP000000226}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. G19833 {ECO:0000313|Proteomes:UP000000226};
RX PubMed=24908249; DOI=10.1038/ng.3008;
RA Schmutz J., McClean P.E., Mamidi S., Wu G.A., Cannon S.B., Grimwood J.,
RA Jenkins J., Shu S., Song Q., Chavarro C., Torres-Torres M., Geffroy V.,
RA Moghaddam S.M., Gao D., Abernathy B., Barry K., Blair M., Brick M.A.,
RA Chovatia M., Gepts P., Goodstein D.M., Gonzales M., Hellsten U.,
RA Hyten D.L., Jia G., Kelly J.D., Kudrna D., Lee R., Richard M.M.,
RA Miklas P.N., Osorno J.M., Rodrigues J., Thareau V., Urrea C.A., Wang M.,
RA Yu Y., Zhang M., Wing R.A., Cregan P.B., Rokhsar D.S., Jackson S.A.;
RT "A reference genome for common bean and genome-wide analysis of dual
RT domestications.";
RL Nat. Genet. 46:707-713(2014).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CM002288; ESW32587.1; -; Genomic_DNA.
DR RefSeq; XP_007160593.1; XM_007160531.1.
DR AlphaFoldDB; V7CQU9; -.
DR STRING; 3885.V7CQU9; -.
DR EnsemblPlants; ESW32587; ESW32587; PHAVU_001G000700g.
DR GeneID; 18639915; -.
DR Gramene; ESW32587; ESW32587; PHAVU_001G000700g.
DR KEGG; pvu:PHAVU_001G000700g; -.
DR eggNOG; KOG1430; Eukaryota.
DR OMA; YFPLDEH; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000000226; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028110; TMEM254.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF14934; TMEM254; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000226};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 299..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..295
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 478 AA; 53705 MW; 8D3F324ED6D80038 CRC64;
MHLSENEGIE GKTFVVTGGL GFVGSALCLE IIRRGAREVR AFDLRSSSPF SPALRDKGVR
FIQGDVGRKE DVERALRGAD CVFHLAAFGM SGKEMLQFGR VDEVNINGTC HVLDACIDLG
ITRLVYCSTY NVVFGGQQII NGNEALPYFP IDHHADPYGR SKSIAEQFVL KNNARALKNH
SGNRLYTCAI RPAAIYGPAE DGHLPRIVTM AKLGLLLFRI GDQTVKSDWL FVDNLVLALI
LASMGLLDDN RSQAKRPVAA GQAYFISDGS PVNSFEFLQP LLRSLDYELP KTSLPVDRAL
VLGRICWAVY TILYPWLNRW WLPQPFILPS EVHKVGVTHY FSYLKAREEI GYVPMVTSRE
GMALTISYWQ QRKRATLDGP TIYAWLFCVI GMISLFCGAF LPDKGIVFLL RAICLFVFRS
MWVTRLVFLL ATTAHIAEAI YAWYLAQRVD PANARGWFWQ TFALGMFSLR LLLKRART
//
