ID V7HW93_9LACO Unreviewed; 1512 AA.
AC V7HW93;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Lactocepin or PrtP {ECO:0000313|EMBL:ETA73545.1};
GN ORFNames=LEQ_1490 {ECO:0000313|EMBL:ETA73545.1};
OS Ligilactobacillus equi DPC 6820.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Ligilactobacillus.
OX NCBI_TaxID=1392007 {ECO:0000313|EMBL:ETA73545.1, ECO:0000313|Proteomes:UP000018559};
RN [1] {ECO:0000313|EMBL:ETA73545.1, ECO:0000313|Proteomes:UP000018559}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DPC 6820 {ECO:0000313|EMBL:ETA73545.1,
RC ECO:0000313|Proteomes:UP000018559};
RX PubMed=24435863;
RA O'Donnell M.M., Harris H.M., O'Toole P.W., Ross R.P.;
RT "The Genome of the Predominant Equine Lactobacillus Species, Lactobacillus
RT equi, Is Reflective of Its Lifestyle Adaptations to an Herbivorous Host.";
RL Genome Announc. 2:e01155-e01113(2014).
CC -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01240}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETA73545.1}.
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DR EMBL; AWWH01000174; ETA73545.1; -; Genomic_DNA.
DR RefSeq; WP_023860239.1; NZ_AWWH01000174.1.
DR PATRIC; fig|1392007.3.peg.1646; -.
DR Proteomes; UP000018559; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd07475; Peptidases_S8_C5a_Peptidase; 1.
DR Gene3D; 2.60.40.4070; -; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR Gene3D; 2.60.40.1710; Subtilisin-like superfamily; 1.
DR InterPro; IPR034216; C5a_Peptidase.
DR InterPro; IPR010435; Fn3_5.
DR InterPro; IPR022263; KxYKxGKxW.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR NCBIfam; TIGR03715; KxYKxGKxW; 1.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR PANTHER; PTHR43399; SUBTILISIN-RELATED; 1.
DR PANTHER; PTHR43399:SF4; TK-SUBTILISIN; 1.
DR Pfam; PF06280; fn3_5; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF19258; KxYKxGKxW_sig; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000018559};
KW Secreted {ECO:0000256|ARBA:ARBA00022512};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..45
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 46..1512
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004760804"
FT TRANSMEM 1487..1506
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1476..1512
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 58..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 131
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 196
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 393
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 1512 AA; 161887 MW; 6FE76ECA54660DA3 CRC64;
MKKNYCTEEK RHYKLYKAKS RWLVAAITTS GLVLLATAPA SQAQADSVDE VTVTQTTNNQ
VTTNSQNADT EQTTNQVQTN TQTATANQTE NVATSADVTP ATTEKDHVKG NVQAAWDQGY
QGQGMVVSVI DSGADTNHKD FAQAPKDPAI SKEEAQAQIN KLGYGTYASE KFPFVYNYAS
RSNDWIKDDG PDASQHGQHV SGIIGANGQA NGTDKYAVGV APEAQLMMMR VFNGQFADEN
TDDIAQAIYD AVKLGANVIQ MSLGQGVAAN NLNDVEQKAV QYATEHGVFV SISASNSGNG
ASVAGDDLPY RPGGPAGNFS PFSSSTVANP GASVNALTVA AENSDLGDAS DMASFSSWGA
LPDFTLKPDL SAPGVSVVST GNDNGYNTMS GTSMAGPFNA GAAALVMQRL KATTDLTGFA
LVQATKALLM NTARPMTQVK YTTPVSPRRQ GAGQIDVGAA TASPVYITAA DGTSSLSLKQ
VGESTNFTLT FTNLSNQDQT YTFDDFGGGL TEKRDEKSGI FYDEYLAGAH VNGPQTVTIK
AGQSANFTYS LNLTGLKKNQ LVEGWLRFTN QKGQAQLVVP YLAYFGDMTT EDVFDKAANQ
DGTIFGGNYF VNENNFPRGI ADQESLKALV NLDGKYNWQQ VAKLYQDGKV AFSPNNNGAS
DILKPYAFIK QNLKDLKIQI LDANGKVVRT VADEQGLDKS FYNSGNNQDI TLSVSMRNDR
DTLDWDGKLY NDQTGQMETA PDGQYTYRYI ATLYNEGDKQ VQSADYPVVI DTTAPVISNL
AYDETTHTLS FDYQDQGAGF TDYSYAIVKV NNQAFGYKLK DGDSHFTNDG KTAGHFQAVL
NAATLAAFTT AKNALSVAVT DVADNGTSQT LVLAAPDVNT NSVNLWNATN GLAFDQTSPD
YNATNKTYTL RGSANQDFYY KGALVQVATD GTFALPVATN VEQVVLTADQ AGQKVLTTLK
TSTPKAAFAW QVANTEPHSF GPMLNTVIGN NPDDVVVQAA VTVGDNVKAY AQDYFSGELY
EAEVKDGLAT FHIHDALRTV LVGWTEVTGP NFNDVQTTPS AGVYLGVMAS ASYPAPGPAF
TKASQLGTDL VQEKADSATL GNPDTLPGHA VTDLTTKAPA NTEINFDYLT DNDYNWVGAK
AITDGVYDPE NQVFTVTGKV TPEVTALTIL GDSSNESDPA NQVALQADGS FTFSFHVAPT
AQRPIAYIYT TSAGQTRGTM ELILDTALPS LDLADAQSYQ LDADGNYQIY TNNPNFTLAG
TANDNVDGYR FFVNGNNEYR EFHNSGVNFV AEAHTDGTTV TNPYPAHKFN HSFDLRADGQ
NETTHVYTLK VTDVVGNTVE KKFYVHYQAQ ATTDTKVVTQ KQAATTLLDY ATEASQLKDA
KGDLQAVTGT DLTPGQYRLF NKYGNLVLNL TVTPDPEVHT TSENNVDVQK QELTNTDAKA
EVDNKSEVQT EGKVTSAPQA QKVATKVVAA KHQASLPQTG EKQASTTSLG VLALALATLC
GLFGFGKSKK ED
//
