ID V8CEU4_9HELI Unreviewed; 621 AA.
AC V8CEU4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE AltName: Full=Omega-protein {ECO:0000256|ARBA:ARBA00032877};
DE AltName: Full=Relaxing enzyme {ECO:0000256|ARBA:ARBA00032235};
DE AltName: Full=Swivelase {ECO:0000256|ARBA:ARBA00030003};
DE AltName: Full=Untwisting enzyme {ECO:0000256|ARBA:ARBA00031985};
GN ORFNames=HMPREF2087_01435 {ECO:0000313|EMBL:ETD25607.1};
OS Helicobacter canis NCTC 12740.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1357399 {ECO:0000313|EMBL:ETD25607.1, ECO:0000313|Proteomes:UP000018688};
RN [1] {ECO:0000313|EMBL:ETD25607.1, ECO:0000313|Proteomes:UP000018688}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 12740 {ECO:0000313|EMBL:ETD25607.1,
RC ECO:0000313|Proteomes:UP000018688};
RG The Broad Institute Genomics Platform;
RA Earl A., Fox J.G., Shen Z., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Abouelleil A., Alvarado L., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Helicobacter canis NCTC 12740.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IA topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00009446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETD25607.1}.
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DR EMBL; AZJJ01000007; ETD25607.1; -; Genomic_DNA.
DR RefSeq; WP_023930445.1; NZ_KI669458.1.
DR AlphaFoldDB; V8CEU4; -.
DR STRING; 1357399.HMPREF2087_01435; -.
DR PATRIC; fig|1357399.3.peg.1500; -.
DR eggNOG; COG0550; Bacteria.
DR HOGENOM; CLU_002929_4_3_7; -.
DR OrthoDB; 9804262at2; -.
DR Proteomes; UP000018688; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00186; TOP1Ac; 1.
DR CDD; cd01028; TOPRIM_TopoIA; 1.
DR Gene3D; 3.40.50.140; -; 1.
DR Gene3D; 1.10.460.10; Topoisomerase I, domain 2; 1.
DR Gene3D; 2.70.20.10; Topoisomerase I, domain 3; 1.
DR Gene3D; 1.10.290.10; Topoisomerase I, domain 4; 1.
DR InterPro; IPR000380; Topo_IA.
DR InterPro; IPR003601; Topo_IA_2.
DR InterPro; IPR013497; Topo_IA_cen.
DR InterPro; IPR013824; Topo_IA_cen_sub1.
DR InterPro; IPR013825; Topo_IA_cen_sub2.
DR InterPro; IPR013826; Topo_IA_cen_sub3.
DR InterPro; IPR023405; Topo_IA_core_domain.
DR InterPro; IPR003602; Topo_IA_DNA-bd_dom.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR42785:SF1; DNA TOPOISOMERASE; 1.
DR PANTHER; PTHR42785; DNA TOPOISOMERASE, TYPE IA, CORE; 1.
DR Pfam; PF01131; Topoisom_bac; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00417; PRTPISMRASEI.
DR SMART; SM00437; TOP1Ac; 1.
DR SMART; SM00436; TOP1Bc; 1.
DR SMART; SM00493; TOPRIM; 1.
DR SUPFAM; SSF56712; Prokaryotic type I DNA topoisomerase; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Reference proteome {ECO:0000313|Proteomes:UP000018688};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 1..104
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 621 AA; 71389 MW; F30D608157C8DD14 CRC64;
MPLIIIESPN KVEKIKQITG YEVIATAGHF MELKHIDIDN GYAAVFDYVE SKKYSIMRAI
EKSKNEIVYI ASDPDREGYA IGYHFYQKIK NVAKTIYRAE FHEITPSGIK NGLDNAKLFI
DTNLNFYQSF LGRRVSDQLI GFILSPYLTR GLESKNILSA GRVQTPALSL ITIREEEIKA
FHSLSDSEKK EYALRARSIV DGKELVFKHT ENGKEIKYPT QESLQALLQE LVGFDKALIT
KIEKTSVSSS PEKPFTTSKL LKKASKKLGI STQRIQTLAQ ELFAKGLITY IRTDSESLSK
EFLLEMQSFY ADIYPNSYKY TTYKAGKHSQ AEAHEAIRIT HCHRYEEIAS ICAKEGLDSD
HIKLYTLIFK NTIASQNKSA VYEKTDVYLN IKMTEFKISF KKIIDKGYLG IFEDSADETK
EAEQEITSFP YNEKDFLPIS QVFIKDIDKA PPKRYLEADF IEVMEKSGIG RPSTYAKYLP
TLLSKEYIQI SNDKKREIYP TALGISVINF FKRDKNAWLL DLSFTAQMEQ ALDEIMSGEK
KYVAYMQDVH SKMEFIPLKA EPKEKKEYPP SPKQIKFCED IAKILNIELP NDYNKHYKIA
GDFISKYSKQ IPKKDYKKDN H
//
