ID V8N7Z1_OPHHA Unreviewed; 1079 AA.
AC V8N7Z1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Microtubule-actin cross-linking factor 1, isoform 4 {ECO:0000313|EMBL:ETE58230.1};
DE Flags: Fragment;
GN Name=MACF1 {ECO:0000313|EMBL:ETE58230.1};
GN ORFNames=L345_16044 {ECO:0000313|EMBL:ETE58230.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58230.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE58230.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE58230.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE58230.1}.
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DR EMBL; AZIM01006997; ETE58230.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 7.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF34; MICROTUBULE-ACTIN CROSS-LINKING FACTOR 1, ISOFORMS 1_2_3_5; 1.
DR Pfam; PF00435; Spectrin; 2.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00150; SPEC; 7.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 5.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 988..1023
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1024..1059
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 293..323
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE58230.1"
SQ SEQUENCE 1079 AA; 121775 MW; 754DB5BB40A3680E CRC64;
MEAERLWHQG SCWQAAQEDL PLAFRGSRDR WTQLEEELLT RQACHLPHPP REPHSLWASL
AAPAGGRSPA PXHRLEAALL RLGQFQSQLD WLLQWLLSTE EQLQNPLLLS PDLQSCEIEL
AKHQRVAFWW TIGETYAVSR QVLQKDVLSH SMTVQAMQEA GWCLQLPDDG SGARTEDLQG
SLRQLSHRWN QVLAKTEHRQ LALEHNLSQV RPSERPYGQV FPGLEGLCSR PGGGCLLKPG
GSFCPPHPLH SAHCLRLVLP KVREISLEVA GLVQWLDQVE LQLFSSKPTW DPSEATKDKL
AALLELCEEM ESKRQTYQQV QEKLQPLLAS CHPNRASTAE RSLRALEQKW ASLTSCLQEQ
KEQLLRSPNT ATRFRATLQK LLKWVKQTEE ALAALPPPSY ILDTVSKQRR QQQALAQEAE
AQSKKLAGMA VGVACLAQDN GGPRSLVGNA KERLAKVLQQ VTERGEVLEE AHQQAKQFRE
SWQLLLGWMD GAEAACSAPA GAPPAKPEDL KALLGQHKGF QRHLRAKRPI FEAALQQGGL
LRDRALLPAD GQELDAMQRE LKERWGALWS WAAERQQKLE ELLLSSSCSS DALQSLLDCL
CRVEPQLAEE TPVAGDRDLV GTLMEQYKAF QTELGQRVVS VGTLRCSAQE LAQGGSSVDT
RWLQIQMEEL EERWELIGRL SVSQQNRLEG ALRQACGQAR GQRCKKDSWA EESHRLLCTF
LSRLSGLEKS VMDGAPPEEE EEALTEGQSQ LEGGADGFAH RQQELQQRVQ CQRLELDCIS
SLGEEILSAC HPDAVGTIHS WVDLAKSCFQ QLCSWVQRQE QRLQAQAASL AVDRKALEQF
SDWITAAEEA LSLRDQEPLP EDARQLEELG CQHTELGHKQ AEVEKAAKNG RQERAAQLGA
TASSCQRSSG WHGTSRALPQ SPLVPLEDLE PQNPLLAQLV HRWQCLWLAA QDRQHRLQRS
QQHHQELEER AGFDFAAWRK RYLQWIRHRK SRVLDIFRSI DWGQDGRLTQ QEFIGRVLAS
KFPTSLPEMK AVAKIFDMNR DGFIDYYEFI HTLHPSQDVL QRAANVDDIQ EEGALRRFL
//
