ID V8N9T4_OPHHA Unreviewed; 672 AA.
AC V8N9T4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Amyloid beta A4 precursor protein-binding family B member 1-interacting protein {ECO:0000256|ARBA:ARBA00040699};
DE AltName: Full=APBB1-interacting protein 1 {ECO:0000256|ARBA:ARBA00042746};
DE Flags: Fragment;
GN Name=APBB1IP {ECO:0000313|EMBL:ETE58701.1};
GN ORFNames=L345_15577 {ECO:0000313|EMBL:ETE58701.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58701.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE58701.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE58701.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the MRL family. {ECO:0000256|ARBA:ARBA00038382}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE58701.1}.
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DR EMBL; AZIM01006403; ETE58701.1; -; Genomic_DNA.
DR AlphaFoldDB; V8N9T4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16137; RA_MRL_RIAM; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243:SF14; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B MEMBER 1-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 164..251
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 294..403
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 428..454
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..622
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE58701.1"
SQ SEQUENCE 672 AA; 74981 MW; 7506D4EE91B58525 CRC64;
MCSLEVEAMP TPQQKSPDVE AMPIAYQKSS DAEFNFAVGF KDLNESLNTL EDTDLDTLMA
DLIADISEVE KTTLQEPKNT SYNEQGAIMQ PPAKPAPICG TQSMLSNIPP PGVNKFPAPP
AEMLMPLPPP LAIPPKPLTQ EAQEQAKADK IKLALEKLKE AKVKKLVVKV HMNDNSTKSL
MVDERQVACD VLDNLFEKTH CDCNINWCLY EIYPELQIER FFEDHENVIE VLSHWTRDSE
NKILFLEKNE KYAVFKNPQN FYLSNKGKNE SKEMNEKSKE ALLEESFCGT SVTVPEVEGA
LYLKEDGKKS WKRRYFLLRA SGIYYVPKGK TKTSRDLACF IQFDNVNVYY GMQYKMKYKS
PTDYCFVLKH PQIQKESQYI KYLCCDDKES LHLWVTGIRI AKYGKALYDN YIGAVQKSEL
ASRLAKPGNT KSIASEGSSS KGSSHANGQI PQNITLNTVI TAETGKSADM PKIQMNVKKP
DDTFNGGQTS SLPVQQVKQI RKRSGFHPPP PPQRRSSAVT ATLDLSSITE RENPTFLPNY
EEFPPPPEFI PLPPNLEDLP PPPPPPPPPS PPLPEYCESP PDFTPPPPPF LPTGIGSAEL
LPPPPPPSCS APGLPPATKK KPPPPPRRQE EGACQVVRPK QSGSISRQHV SEQGDFMSDL
MRALQKKRSE SS
//
