ID V8N9Z5_OPHHA Unreviewed; 771 AA.
AC V8N9Z5;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Atrial natriuretic peptide receptor 2 {ECO:0000256|ARBA:ARBA00044153};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
DE AltName: Full=Atrial natriuretic peptide receptor type B {ECO:0000256|ARBA:ARBA00044222};
DE AltName: Full=Guanylate cyclase B {ECO:0000256|ARBA:ARBA00044260};
DE Flags: Fragment;
GN Name=NPR2 {ECO:0000313|EMBL:ETE58463.1};
GN ORFNames=L345_15815 {ECO:0000313|EMBL:ETE58463.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58463.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE58463.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE58463.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone.
CC Has guanylate cyclase activity upon binding of its ligand. May play a
CC role in the regulation of skeletal growth.
CC {ECO:0000256|ARBA:ARBA00043880}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE58463.1}.
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DR EMBL; AZIM01006707; ETE58463.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF508; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 2; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Osteogenesis {ECO:0000256|ARBA:ARBA00022855};
KW Receptor {ECO:0000313|EMBL:ETE58463.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..771
FT /note="Atrial natriuretic peptide receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004770586"
FT TRANSMEM 189..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 316..663
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 681..725
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 500..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 618..645
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 500..521
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE58463.1"
SQ SEQUENCE 771 AA; 86113 MW; 4CB0E4D577F48C1A CRC64;
MGGKGWRLSC RGTWASMSLG QWPFLQTVLV ITYHEPQTLE YRDFQNKLIL RARQEYQVEL
SGSLKNLVAG CFHDGLLLYA LALNETLHEG DTKLNNSRIL EKMKGRRFQG VTGTVSMDQN
NDRDTDFNLW AMTEGDSGAY QVVGHYVGSE KQLKWLGPIY WVKGQPPLDN PPCFDMDDPS
CDKSALSTLA ILALGAGLTF IMFGVSSFLI FRCLSKLLGG LEYSGREGGV PWPDRQCAAR
EEEGHSALNP AWVQLQGTGG RGVSHGAMAW SGSSGAIVGL GRKLMLEKEL ASMLWRIRWE
DLQFGGTERY HKGAGSRLTL SLRGSSYGSL MTAHGKYQIF ANTGLFKGNV VAIKHINKKR
IELTRQVLFE LKHMRDIQFN HLTRFIGACI DPPNICIVTE YCPRGSLQDI LENESINLDW
MFRYALINDI VKGMAFLHNS IIGYHGSLKS CNCVVDSRFV LKITDYGLAS FRQGHESEGN
HALYASECLA SPPPXXPPWL PPCLSPGEAQ APHPLTPDSP APAPEKLWTA PELLQKGTLL
PLPLAMQKAD VYSFGIILQE IALRSGAFYV EGIELSPKEI VQKVGNSQLP YFRPTIDTRL
HSEELAVLME REGSTSILDN LLSRMEQYAN NLEKLVEERT QAYLEEKRKA ENLLYQILPH
SVAEQLKRGE TVQAEAFDCV TIYFSDIVGF TSLSAESTPM QVVTLLNDLY TCFDAIIDNF
DVYKIHISAA TKEILDEFGC FLLELRGDVE MKGKGKMRTY WLLGEEKASV I
//
