ID V8NAG9_OPHHA Unreviewed; 557 AA.
AC V8NAG9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Bifunctional coenzyme A synthase {ECO:0000313|EMBL:ETE58648.1};
GN Name=COASY {ECO:0000313|EMBL:ETE58648.1};
GN ORFNames=L345_15629 {ECO:0000313|EMBL:ETE58648.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE58648.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE58648.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE58648.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE58648.1}.
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DR EMBL; AZIM01006467; ETE58648.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NAG9; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004140; F:dephospho-CoA kinase activity; IEA:InterPro.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:InterPro.
DR CDD; cd02022; DPCK; 1.
DR CDD; cd02164; PPAT_CoAS; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00376; Dephospho_CoA_kinase; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR001977; Depp_CoAkinase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR00152; dephospho-CoA kinase; 1.
DR PANTHER; PTHR10695:SF64; BIFUNCTIONAL COENZYME A SYNTHASE; 1.
DR PANTHER; PTHR10695; DEPHOSPHO-COA KINASE-RELATED; 1.
DR Pfam; PF01121; CoaE; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51219; DPCK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 190..332
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
SQ SEQUENCE 557 AA; 61942 MW; 85FC21940F6E4EB7 CRC64;
MVLPDSMSIF RSGLLVLTSP LPALSLRLMP ILASAARLVQ ETLYIQLQPG LSLSGATQPR
FAYIPATSEV HNLISKLYAD ADLHRHLDVR ILLTNLLNQG ANPPLLGSVQ NLSQPPEVVL
TDYESADGAQ SNPIKQCLER YAISCYSCCP KLRSVLLYPD YELQDDNGEL SPQEETEKTN
EPLQSFSDVV VGGTFDRLHN GHKILLSVSC LLAENRLLIG VSDKDLLENK LLKELILPFE
QRLDQLAEFL VDVKPTLQFD IVPLYDPFGP SITDANLKCI VVSEETFKGG LSVNRRRAEN
NLSELALHKI NLAVDPQHAR NEEEKISSSS LRYRLLGTLL CAPQKNPSLP SSPYIIGLTG
GSGSGKSSVA QYLFHLGAFH LDMDRLGHNI YTPGGPVYKQ VIEAFGPDIL NEDGTINRKL
LGAKVFGDQE QMKQLNNIMW PVMAQMAKEK IEEAAKQGKT VCVLDAAMLL EAGWTKMVHE
VWTVIIPENE AIRRIIERDG LSSEAAKLRI QSQMPNSQRV KHSHVVLCTM WEPEITHEMV
DKAWALLQKR IKPEIDP
//
