ID V8NC81_OPHHA Unreviewed; 509 AA.
AC V8NC81;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
DE Flags: Fragment;
GN ORFNames=L345_15013 {ECO:0000313|EMBL:ETE59258.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59258.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE59258.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE59258.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE59258.1}.
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DR EMBL; AZIM01005721; ETE59258.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NC81; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd21817; IgC1_CH1_IgEG; 1.
DR CDD; cd05768; IgC1_CH3_IgAGD_CH4_IgAEM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR PANTHER; PTHR23411:SF30; IMMUNOGLOBULIN HEAVY CONSTANT EPSILON; 1.
DR PANTHER; PTHR23411; TAPASIN; 1.
DR Pfam; PF07654; C1-set; 4.
DR SMART; SM00407; IGc1; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS00290; IG_MHC; 4.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..509
FT /note="Ig-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004770771"
FT TRANSMEM 465..489
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 127..219
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 243..333
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 342..441
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE59258.1"
SQ SEQUENCE 509 AA; 58063 MW; 7F9052D43C1B68CC CRC64;
MEYKFTIFTV LFLSSPTAVK TAPTVFPLSP CNQDITTSFQ VSIGCLVKGY FPQPATVQWN
SGAITSGIHN FPPVLLGSDH YTHSSMLTIP VSQWQSESFQ CNVHHEATDT RINKIIDRSA
IRSPVGPKIQ MYHSSCDSRD GVIQLWCQIL DFYPKQLDIE WKVGSRSGLL RPYNYPSWQN
PGTYTFSTNS VVNITQDDWL EGNVYYCEVT HSASQTKVKG KLKKCEGGSS CPSGDVNVYL
VPPRPRALYI NRDSKISCVV NNLQNEQGLK ITWSREKNGY LNVDVIEIVE EPNGTYTAVS
RLNVVAQDWE SGETFTCRVE HPSFVSPLTK NIFKTRGNKK APKVYVFPPH RDELNPGTSV
SLLCMINRFS PSAIDIQWLH DYNPVSEDKY VTTPAMKNKH DDSFFAMSKL SISREDWNEG
QYTCMVVHED LPMKFTQRNI SKTQVFVVIM ENDYSLEKEE ELEHLWTILF IFFILFLFSV
SYSAIITLFK VSKMVFFYND TTEEETNIP
//
