ID V8NC98_OPHHA Unreviewed; 397 AA.
AC V8NC98;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Cell growth-regulating nucleolar protein {ECO:0000313|EMBL:ETE59551.1};
DE Flags: Fragment;
GN Name=Lyar {ECO:0000313|EMBL:ETE59551.1};
GN ORFNames=L345_14720 {ECO:0000313|EMBL:ETE59551.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59551.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE59551.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE59551.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE59551.1}.
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DR EMBL; AZIM01005497; ETE59551.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NC98; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1490.490; -; 1.
DR InterPro; IPR039999; LYAR.
DR InterPro; IPR041010; Znf-ACC.
DR InterPro; IPR014898; Znf_C2H2_LYAR.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR13100:SF10; CELL GROWTH-REGULATING NUCLEOLAR PROTEIN; 1.
DR PANTHER; PTHR13100; CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR; 1.
DR Pfam; PF17848; zf-ACC; 1.
DR Pfam; PF08790; zf-LYAR; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR PROSITE; PS51804; ZF_C2HC_LYAR; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01145}.
FT DOMAIN 42..67
FT /note="Acetyl-coA carboxylase zinc finger"
FT /evidence="ECO:0000259|Pfam:PF17848"
FT DOMAIN 70..97
FT /note="Zinc finger C2H2 LYAR-type"
FT /evidence="ECO:0000259|Pfam:PF08790"
FT REGION 201..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..220
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE59551.1"
SQ SEQUENCE 397 AA; 45970 MW; 7762B87F708C9BAA CRC64;
MSSPAHYMQR QIVNSVLDVL FPGFVGRAVN QTPKKRIPRM VFFTCNACGE ALKKGQVEKH
VHVCRNCQCL SCMDCGKDFW DDDYKYHVKC LSEDQKYGGK NYEAKVLKGD VKQQEWIQKI
HEIIKETNIN AKVRDILQQM YEYDNIPRKK RKFQNWMANS LKIHNTTLQD QVWDIFSEAT
RKETFETQSL KNEIMPVASE KNITKTEKPK EKKGKKELKE KKSIRKLKAQ QENLECLKSE
KSRQDLLEEG SKKMLQSDYL KKAKQEAVGL VEVQRKGNGA EAEEAEAEAR GKKRKNSCTK
ADESPIPTKI MNRSEVEENK DKHQGKFNWK GTITAVLKQA PDNELSIKKL RKKVIAQYYA
VTGDHQKSEE ETLALLKKKV SSNPKFRVLK EKVKLLK
//
