ID V8NCB6_OPHHA Unreviewed; 826 AA.
AC V8NCB6;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=GTPase-activating protein and VPS9 domain-containing protein 1 {ECO:0000313|EMBL:ETE59914.1};
DE Flags: Fragment;
GN Name=GAPVD1 {ECO:0000313|EMBL:ETE59914.1};
GN ORFNames=L345_14353 {ECO:0000313|EMBL:ETE59914.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE59914.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE59914.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE59914.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE59914.1}.
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DR EMBL; AZIM01005128; ETE59914.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NCB6; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd05129; RasGAP_RAP6; 1.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR045046; Vps9-like.
DR PANTHER; PTHR23101:SF25; GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 107..336
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 429..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..738
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE59914.1"
FT NON_TER 826
FT /evidence="ECO:0000313|EMBL:ETE59914.1"
SQ SEQUENCE 826 AA; 91681 MW; 46B2E66EC7557548 CRC64;
MVKLDIHTLA HHLKQERLYV NSEKQLIQRL NAEVLKTAEK LYHTAWISKQ QRINLDRLII
TSADASPAEC CQHAKVLEDT QFVDGYKQLG FQETGYGEFL HRLRENPKTP DADFLRRLRE
NPRLIASCLV AGEKLSQESI QNVIHTVFTS LYGNCIMAED ESFLLQLFSE GLFSAKLFLT
ATLHEPIMQL LVEDEDHLET EAHKLIERFS PAQQEKLFGE KGSERFRQRV QEMVDSNEAK
LVALVNKFIG YLKQNTYCFP HSLRWIMSQM YKTLSCVERL EVGEVRAMCT DLLLACFICP
AVVNPEQYGI ISDAPINEVA RFNLMQVGRL LQQLAMIGSE DGDPRTKANL GKFDKGCVAS
FLDVVIGGRA VETPPMSSVN LLEGLSRTVV YMTYSQLTTL VSFMRNVMSG DQLKEDRVAL
ENLLLNLPQN KPGKTTRSRS RSNIQMDQHP DYEGFSQETI QEVQLEEVLV ISLGTGPQIT
PGMMSENEVL NMQLADGSQG EVPVDDSKLH GKPDKTLRFS LCSDNLEGIS EGPSNRSNSV
SSLDLEGESV SESGAGPSGS NGVEALQLLE REQATTQDNL DDKLRKFEIR DMMGLTEDRD
ISETVSETWS TDVLGSDFDP NIDEDRAAAE NVLGSLLCLP GSGSVLFDPC TGSTISETTS
EAWSVEVLPS DSGEESPSDL KQEERLQELE SCSGVGSASD DTDVREVSSR PSTPGLSVVS
DRKDSDDEKS DRNKPWWRKR FVSAMPKGKS GGREGGKIEG KEEGRKGGRK KEEVEVSKEG
GKKEEEVEGK DAKKKLRLAL CSADSVALPV LSHSTRNGLP DHTDPE
//
