ID V8NCS8_OPHHA Unreviewed; 544 AA.
AC V8NCS8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 1 {ECO:0000313|EMBL:ETE60049.1};
DE Flags: Fragment;
GN Name=Scube1 {ECO:0000313|EMBL:ETE60049.1};
GN ORFNames=L345_14213 {ECO:0000313|EMBL:ETE60049.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60049.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE60049.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE60049.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE60049.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01005008; ETE60049.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NCS8; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF4; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF14670; FXa_inhibition; 3.
DR PRINTS; PR00907; THRMBOMODULN.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 4.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS01187; EGF_CA; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 149..189
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 190..228
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 194..204
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT NON_TER 544
FT /evidence="ECO:0000313|EMBL:ETE60049.1"
SQ SEQUENCE 544 AA; 60073 MW; 57CEF84E2E140BCC CRC64;
MNCMNKDHGC EHICRETPKG GVACECRPGF ELAKNQKDCK LTCNYGNGGC QHTCDDTDSG
PVCGCHQKYA LHSDGRTCIE KDEAAIESSE FNATSVADVD KRVKRRLLME TCAVNNGGCD
RTCKDTATGV RCSCPVGFTL QPDGKTCKDI DECLVNHGGC DHFCRNTVGS FQCSCQKGYK
LLTDERTCQD IDECSFERTC DHTCINYPGS FECLCHNGYT LYGMTHCGDV DECSINNGSC
DYGCLNTVGT YECLCPSGKK LHWNKKDCVE MVKCLPGANP VPKAQLLCSK SGGIENCFLF
CPSNTLFVPD SENSYSVSCG VPIQQGKSQQ KRNSTLPGCM DILMPPIKQK ARFKIKDAKC
HFRPRNKEKI KEVGKQQTLL GGQFPCADNC HITFVNLKCD SSKKKRRGRK SPSKEVSHIT
AEFEMEMKSE EVSDTCNVDC LRKRMEQKLQ TAIKTLRKSI NKQQFYIQFS GTEYEIAQKA
AKIVSEGHSC STGQLPAALA PIIVENIINA SLAHQERIKK QKVSSPVNLA QGMMGKALKV
QEVC
//