ID V8NEW1_OPHHA Unreviewed; 555 AA.
AC V8NEW1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Plastin-1 {ECO:0000313|EMBL:ETE60102.1};
DE Flags: Fragment;
GN Name=PLS1 {ECO:0000313|EMBL:ETE60102.1};
GN ORFNames=L345_14161 {ECO:0000313|EMBL:ETE60102.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE60102.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE60102.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE60102.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE60102.1}.
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DR EMBL; AZIM01004962; ETE60102.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NEW1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:InterPro.
DR CDD; cd21326; CH_PLS1_rpt2; 1.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039959; Fimbrin/Plastin.
DR PANTHER; PTHR19961; FIMBRIN/PLASTIN; 1.
DR PANTHER; PTHR19961:SF27; PLASTIN-1; 1.
DR Pfam; PF00307; CH; 4.
DR Pfam; PF13499; EF-hand_7; 1.
DR SMART; SM00033; CH; 4.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 3.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 21..56
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 61..96
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 90..193
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 221..332
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 442..551
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE60102.1"
SQ SEQUENCE 555 AA; 62176 MW; 09308B8FBBE4989E CRC64;
MDDIKKLAIK MENNVTTISR EELEELKEAF SKIDIDNSGY VSDYELQDLF KEASLPLPGY
KVREIVEKII AVADSNKDGK INFEEFVSVK EDKVAFVNWI NKALKDDPDC KHCLPMNPSD
DSLFNSLADD TIDERAINKK KLTAFTRSEN LDLALNSASA IGCTVVNIGS QDLIDGKPHL
VLGLLWQIIK VGLFSDIEIS RNEALIGLLS DEEELEQLMK LSPEELLLRW VNYHLNNAGW
KKISNFGQDI KDSKAYYHLL NQIAPKQGNN GETAIAIDLS GFNEPNDLRR AEYMLQQADK
LGCKQFVTPT DVVAGNPKLN IAFVANLFNT YPALQKPKNN SYDFSLLEGE SKEERTFRNW
MNSLGITPYI NHLYSDLADG LVIFQLYEMI RVPVEWSHVN KPPYPALGGN MKKIENCNYA
VELGKTNARF SLVGIDLGEG EKVNDETIIK WVNQTLANAN KTTSISSFKD QSISTSLPIL
DLIDAIAPKA VRPEMVKRED LTPADKLNNA KYAISIARKI GACIYALPDD LVEVKPKMVM
TVFACLMGRG LNKIK
//
