ID V8NIG1_OPHHA Unreviewed; 202 AA.
AC V8NIG1;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Connector enhancer of kinase suppressor of ras 2 {ECO:0000313|EMBL:ETE61751.1};
DE Flags: Fragment;
GN Name=Cnksr2 {ECO:0000313|EMBL:ETE61751.1};
GN ORFNames=L345_12496 {ECO:0000313|EMBL:ETE61751.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE61751.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE61751.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE61751.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE61751.1}.
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DR EMBL; AZIM01003674; ETE61751.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NIG1; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09511; SAM_CNK1_2_3-suppressor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR049628; CNK1-3_SAM.
DR InterPro; IPR017874; CRIC_domain.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12844; CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS; 1.
DR PANTHER; PTHR12844:SF21; CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2; 1.
DR Pfam; PF10534; CRIC_ras_sig; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51290; CRIC; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ETE61751.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transferase {ECO:0000313|EMBL:ETE61751.1}.
FT DOMAIN 9..58
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 142..202
FT /note="CRIC"
FT /evidence="ECO:0000259|PROSITE:PS51290"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE61751.1"
SQ SEQUENCE 202 AA; 22600 MW; 8E4E8D4E10ACA287 CRC64;
MYAGLDDCLQ QYIKNFEREK IGGDQLLRIT HQELEDLGVT RIGHQELILE AVDLLCALVS
LLASSGVTLM RCMLPLLVCL PADTMPRDHL ESLRAGSFDP GFHSAGLHRV SKPVSKLLQE
GIHIPQLWRP FAMENYGLET ENLKTLSHKL NASAKNLQNF ITGRRRSGHY DGRSSRKLPN
DFLTSVVDLI GAAKSLLAWL DR
//
