ID V8NJ21_OPHHA Unreviewed; 1416 AA.
AC V8NJ21;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Collagen alpha-3(IV) chain {ECO:0000313|EMBL:ETE61522.1};
DE Flags: Fragment;
GN Name=COL4A3 {ECO:0000313|EMBL:ETE61522.1};
GN ORFNames=L345_12727 {ECO:0000313|EMBL:ETE61522.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE61522.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE61522.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE61522.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- FUNCTION: Type IV collagen is the major structural component of
CC glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC together with laminins, proteoglycans and entactin/nidogen.
CC {ECO:0000256|ARBA:ARBA00003696}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE61522.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AZIM01003856; ETE61522.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.320; 6-Phosphogluconate Dehydrogenase, domain 3; 1.
DR Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR001442; Collagen_IV_NC.
DR InterPro; IPR036954; Collagen_IV_NC_sf.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF1100; FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01413; C4; 2.
DR Pfam; PF01391; Collagen; 13.
DR SMART; SM00111; C4; 2.
DR SUPFAM; SSF56436; C-type lectin-like; 2.
DR PROSITE; PS51403; NC1_IV; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Collagen {ECO:0000256|ARBA:ARBA00023119, ECO:0000313|EMBL:ETE61522.1};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Toxin {ECO:0000256|ARBA:ARBA00022656}.
FT DOMAIN 1253..1416
FT /note="Collagen IV NC1"
FT /evidence="ECO:0000259|PROSITE:PS51403"
FT REGION 73..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 493..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..999
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1069..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..124
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..620
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..915
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE61522.1"
SQ SEQUENCE 1416 AA; 139584 MW; 51A5841DD6174364 CRC64;
MGAFLIFRGL LAVEKVKKVS KENQAKEGSQ EKMGKLDCQV CLVFPVNLAR LASQEEMETK
VKKEKLVYLA HLDKPGTGTT VGPKGSKGLA GYPGNKGDRG YPGPVGPPGL PGTPGLPSVG
PSGPPGLPGE RGQKGDQGLS GIAIPGQPGI DGQPGPRGPP GPPGPPGSTI PPGKVIFLII
AHQLLVIHLC DKGDTCFNCI GSGIPGPPGE KGFPGLPGDP GLPGPKGDKG VSGVFGAIGP
QGPPGLPGSP GRPGTKGDPG DMIGFPRMKG EKGNPGFPGP PGLPGLDGSP GKDGLPGRPG
LKGEPGSIAF KGDRGLTGDP GLPGVVGERG PPGPPGFGPQ GPPGEKGLQG VPGRPGSPGA
PGPKGEPAQS VPEKGPPGLP GPPGRNGENG FPGEPGQPGS SGLPGIPGQK GEPGFPGIGL
PGPPGPKGLP GLSGESGLPG NPGRPGADGA PGLPGEKGQK AVKYNSRKHR MDCRVENNYS
ELTFCFLAFQ GERGHGIPGP KGPAGPPGFK GAQGAKGVSG FPGNPGSPGR AGFDGVPGAK
GDPGPRGQPG LVGPPGIPGT GVQGPPGPPG SPGPAGSPGF QGIPGEKGDP GQPGFDVPGP
PGDRGNPGFP GPPGLPGGPG SPGSPGRDGT PGIPGKYILC YSGSVGSKGD MGVMGAPGPL
GTPGSPGRNG FPGSKGNDGL SGQPGQPGLA GQKGSKGEPG LPGAPGKIDI DHLGSKGQKG
EPGEKGNPGL TGQKGYPGLP GDPGPAGSVG QPGAPGLPAW KSIQHQSSNN NSVLIGPKGD
TGIPGGPGPT GPPGLKGANG EMGLPGTPGT KGSQGVPGRV GQPGSPGSPG LKGDKGDPGI
SGIGIPGPPG PKVGCPHSFQ SCDGNRLLRN QKDCFDGRKR GVSTWTPGIP GLKGLDGPPG
SPGVPGPPGP PGELGRPGSP GLLGEKGQPG RDGIPGPSGQ KGEPGQPGFG LPGPQGLPGL
AGKDFILFIS EKESQKGDSG FSGPPGPPGS PGLKGEMGAK GFXFLDHHQK DLRVALGHQA
YQDGQVRKRS NIKVASIAKR MSTKDICSSS HLFALCKISG VHLGFQVGLP GPEGPRGPPG
IGGVKGEKGN PGQTGQPGLP GLKGDQGAPG QLGEPGHPGL NGMKGDSGVP GAPGFPGMKG
PTGPLGPSGP GGDPGPPGSP VVIKGDQGPP GPPGQSGMKG LPGLPGPPGL PGSIGLPGDI
GRDGLPGFDG PAGRKGERGL SGQPGLRGSQ GPPGPDGLQG PPGVPGTGSV AHGFLITRHS
QTTDAPFCPP GTNQIYDGFS LLYVQGNERA HGQDLGTAGS CLRRFSTMPF MFCNINNVCN
FASRNDYSYW LSTPEPMPMS MEPLTGKNIQ PFISRCTVCE APAMVIAVHS QTIQIPSCPQ
GWNSLWIGYS FMMSETLKAG DLRARISRCQ VCMKRT
//
