ID V8NKM9_OPHHA Unreviewed; 1284 AA.
AC V8NKM9;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 {ECO:0000313|EMBL:ETE62615.1};
DE Flags: Fragment;
GN Name=Arap3 {ECO:0000313|EMBL:ETE62615.1};
GN ORFNames=L345_11627 {ECO:0000313|EMBL:ETE62615.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE62615.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE62615.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE62615.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE62615.1}.
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DR EMBL; AZIM01003154; ETE62615.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 4.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 4.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..65
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 474..566
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 580..669
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 675..799
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 971..1069
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1073..1254
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 389..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..410
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE62615.1"
SQ SEQUENCE 1284 AA; 147242 MW; 62611FCE41561170 CRC64;
MHPLCHMDSD IADWLAIIHL ESYQDTFKQH GYVLVKDVTS LCKEDLQKLG ITATGHCKRI
LNLVQQTHLF MDNNSGHMAE DSHSVECTYS SDRPVIKNEE VLAKTISDSE VDHDLASQLQ
QSLLNKESTY PVGKPVPKPR TVFPHDHGTA KLQPVSLSIL LPVHKPTFCS AQGAHNIQER
FDEEKCTTNT QTFDTTSKDQ VHTLASQRET TEDYSGTGVQ TFLHISEMST EGKHFFPSIP
KFSSLCNSQS MDISRTTSLS TAKKIQAETA LVPSALIQSA SLENKKEMVP GVTLPLSAKR
VEMKESLRGG TCTQHSEIVL QNGNFNMKKA GHDWFSNFVY HQMLLTTSSV PITFAYPSIG
LYVCVDWEEE ANSATSEYQD YEDVQKYITN QSKDPIDRNP RREDKSPTAK RETGISSIAQ
NETEGYSTVE ASTDFKSFNS SPFRLPDPIC SVENSDDLTI SPYASYTSLS EQPLFVLNGW
LDKLSPQGNY VFQRRFVRFD GKNLMYFNNE KEPYPKGLIP LYIIGMVRSI KDNKFQIITK
YRIFVFRAEN EAQRNEWCST LQQKVTDKQN LCPPTCSSTH FQKRGYLELK GYKSRLFVIL
ILDEMWLYKS EQFFKMGIAI CLIEMHHSTI RDAKGRNFEL ITPCKIFSFG AESDRQKQEW
MEVLQNSIAE TLYDYEVAEK IWSNKANRFC ADCHALSPGW ASINLCVVIC KHCAGLHRSL
GSRISKVQSL KLDTSIWSNE MVQLFIMLGN RQANKFWAAH LPASEALYPD ANTKQRRDFI
INKYRYGCFR MVHPQYNSQE SILQALCAAV SGPGLLKKMV HFFASTMEVE MGEGIYNEII
QPVVHCGYLY KVPSTAKEIK RSRDEFQRIW CSLEKYFLFY ETERNPEPTV KIEVADMISL
AVNRTDMLAI HSSTDRFCFM LELYLSNERI QQWVGDDSSN LQSWASAIGK NWYLLLQWFT
PLSCHCLLGY EFQRVGRLCY KSMLKPNQWF QGFFILQKFH LFICPEEEGA VEDSINLRQL
QELSIVPLAE SPEKKQMLIL VEMGRTFCLQ GASQLDFSSW CTAIQSSAGS RGNALQDQQL
SKNGIPIIVS SCISFITQYG LQHEGIYRKN GAKSRIKILM EEFRRDARNV KLHISNNFIE
DVTDVLKRFF RELEDTIFTT YLHPQWNEAT EISQKPQRLE RYKELMNCLP HLNHRTLAAL
IGHLYRIQKC VYLNQMSTKN LALLFAPSLF QTNGKGEQEV KVIEDLIDNY VHIFNIDEDQ
VLQMDLENSL ITTWQDGSLF FFSK
//