ID V8NL76_OPHHA Unreviewed; 548 AA.
AC V8NL76;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 15 {ECO:0000313|EMBL:ETE63014.1};
DE Flags: Fragment;
GN Name=ADAMTS15 {ECO:0000313|EMBL:ETE63014.1};
GN ORFNames=L345_11226 {ECO:0000313|EMBL:ETE63014.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63014.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63014.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63014.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|PIRSR:PIRSR613273-2};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR613273-2};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63014.1}.
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DR EMBL; AZIM01002951; ETE63014.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NL76; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 3.40.1620.60; -; 2.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR006586; ADAM_Cys-rich.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR041645; ADAMTS_CR_2.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF39; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 15; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF17771; ADAMTS_CR_2; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 2.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00608; ACR; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000313|EMBL:ETE63014.1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR613273-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Zinc {ECO:0000256|PIRSR:PIRSR613273-2};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 57..127
FT /note="ADAM cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM00608"
FT BINDING 3
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="catalytic"
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-2"
FT DISULFID 9..38
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 68..90
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 79..100
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 85..119
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 113..124
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 140..152
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE63014.1"
SQ SEQUENCE 548 AA; 60976 MW; 40484DB6DEBB0079 CRC64;
MPHDNVKACE EVFGKLKTNH MMSPTLIQID RINPWSPCST AIITDFLDSG HGEEGRGDRY
VYNLNQQCEL AFGIGSKPCP YMQYCTKLWC TGKARGHIMC QTRHFPWADG TSCGEGRFCM
KGACVEKHNI SKYRLAKRQC NNPPPANEGK YCEGVRVKYR SCGLDPCFAS GKSFREEQCE
AFNGYNHSTN RLSSIVSWVP KYSGVSPRDK CKLICRANGT GYFYVLAPKV VDGTPCSPDS
SSLCVQGKCI KAGCDGKLGS KKKFDKCGVC GGDNKSCKKV SGLFTKPMHG YNFVVLLPAG
ASSIDIRQRG YKGLISDDNY LALKNAYGKY LLNGHFIVSA MERDLIVKGS VIRYSGTGTA
VESLQAFMPI QEPLTVEVLS VGKMTPPRVR YSFYLPKESK EDKSSYHRKD GKRPPVLNNS
ILSLSNRLDL GQLDYKRPAY KWATTNWEDC SVTCGNGLQK RMVLCRDVLG QLASSCDATQ
RPVDIRICGD PCPTWEASPW SSCSKTCGRG FKRRILRCTG RGGILLPRER CNLRKKPQEL
DFCTLRPC
//
