ID V8NL99_OPHHA Unreviewed; 1027 AA.
AC V8NL99;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ADAMTS-like protein 2 {ECO:0000313|EMBL:ETE63039.1};
DE Flags: Fragment;
GN Name=ADAMTSL2 {ECO:0000313|EMBL:ETE63039.1};
GN ORFNames=L345_11202 {ECO:0000313|EMBL:ETE63039.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE63039.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE63039.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE63039.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE63039.1}.
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DR EMBL; AZIM01002939; ETE63039.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NL99; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF41; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 988..1026
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT DISULFID 157..198
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 161..203
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 172..188
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE63039.1"
SQ SEQUENCE 1027 AA; 114359 MW; 7214D9242A768488 CRC64;
MESKVFAKLM LCPLVSQYSF HGPEEHLIRC PRVEWKGVTS GQNQRSISIR LRGALKRNAP
EASGLSLLVS TQDEESRTQL GPPSSSWLFP PPEDSHACIV RGERCSGILT VSASSTLPFF
SLLPDGKQDN APASNSLEEG ADVMAYWWGE WTKWAACTRT CGGGIHFQER HCLQQRRKLA
TGFLNKTCNG MSKRYQLCEV QQCPPNGRSF REEQCSSFNS RVYNGRTFHW KPLYPDDYVH
ISSKPCDLHC TTTDGQRQLM VLARDGTSCK SSFFRGVCVS GKCEPIGCDG VLFSPHALDK
CGVCQGNGSS CTHVTGSYRK GNAPLGYSLV THIPAGATDI QIVERKKSAD VLAIADEGGS
YFFNGDYRVD IPQNFNIAGT IFKYRRPMDI FETGIEYIVA QGPTNQGLNI MVWNQNGKKP
SITYEYILQA RPYLKKLPPI YYGFSESGSE EKTEFEEGFL WGLAQLNASL LATLSQEKGH
LEKLLFGRQG RGDELKLSKM QQTNEVEGKN GSELDSLLSS EEFLSENAII HSFGDKRSDS
KESIWNKTLN SIFSPVNPIN TFGPEIDHLY VDYDDSDELL AYAANGTFME LTHEEASNTS
SEIQISNATI SNAGAQGNRT QKARNRLKLF RKGQNMSPAD MYRWKLSSHE PCSSTCTTGV
MSTYAMCIRY DGTEVEDLFC DAATRPEPIH EFCAGRECQP RWETSSWSEC SRTCGEGHQF
RIVRCWKMLS PGLDSSVYSN LCESADIARP EERKVCKNPA CGPQWEMSEW SECTARCGER
SMVSRDIRCS EEERLCDVTT KPAADKNCTG PPCDRQWTVS DWGPCSGGCG PGRMIRQVYC
KSSDGRVVPE SQCNPEAKPL AIHPCGEKNC PAGWLAQDWE RCNATCGRGL KKRTVLCLEI
VSGKIKTRPP ATCDATKKEA EEATCFERPC FKWYTTPWSE CTKTCGIGVR MRDVKCYQGK
DLVRGCDPLL KPVAKQTCDL HPCPTEPPDD SCQDQAGTNC ALAIKVNLCG HWYYSKACCR
SCRVPRS
//
