ID V8NQZ0_OPHHA Unreviewed; 720 AA.
AC V8NQZ0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE Flags: Fragment;
GN Name=DHX35 {ECO:0000313|EMBL:ETE64689.1};
GN ORFNames=L345_09544 {ECO:0000313|EMBL:ETE64689.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE64689.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE64689.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE64689.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE64689.1}.
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DR EMBL; AZIM01002151; ETE64689.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NQZ0; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd17980; DEXHc_DHX35; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ETE64689.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ETE64689.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:ETE64689.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 89..203
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 235..412
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE64689.1"
SQ SEQUENCE 720 AA; 81216 MW; 8A2F63BA2BD2B2B1 CRC64;
MAAPVGPLKF WKPGTEGPGV SLSEERQNAA ESSSVSVIYN PFISLSIEQQ RQKLPVFKLR
NHILYLVENY QTLVIVGETG CGKSTQIPQI AERVAEERGA LLGHEVGYCI RFDDCTDPQA
TRIKFLTDGM LVREMMADPL LTRYSVVMLD EAHERTLYTD IAIGLLKKVQ KKRGDLRLII
SSATLDAEKF RDFFNQNESS DPSKDTSMIL TVEGRTFPVD VFYIQSPVPD YVKSTVETVM
KIHNSEGDGD ILAFLTGQEE VETVVSMLIE QARIIARTGM KKHLRVLPMY AGLPATEQMK
VFERVSHNVR KVIVATNIAE TSITINGISF VVDCGFVKLR AYNPKTAIEC LVVVPISKAS
ANQRAGRAGR NRSGKCYRLY TEEDFEKLPQ STIPEMQRSN LAPVILQLKA LGIDNVLRFP
FLSPPPAQSM VQALELLYAL GGLDKYCRLT EPLGIRIAEF PLNPMFAKML LESGDTLGYE
SEVGVRVHLG YESEVGVRVH LGYESEVGVR VHLGYERNFG CSQEILSIAS MMQIQNIFTV
PPNQKVQAIR EHRKFAVEEG DHLTMLNVYE AFIKHNKSSQ WCQEHFLNYK GLVRATIVRE
QLKKLLVKFK VPKKSSEGDP DPVLRCIVSG FFANAARFHS TGCYRTIRDD HELYIHPTSV
LYAEKPPRWV VYNEVIQTSK YYMRDVTAIK SAWLLELAPH FYQQGTHLSL KAKRAKVDDH
//
