ID V8NST8_OPHHA Unreviewed; 1082 AA.
AC V8NST8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Poly [ADP-ribose] polymerase {ECO:0000256|RuleBase:RU362114};
DE Short=PARP {ECO:0000256|RuleBase:RU362114};
DE EC=2.4.2.- {ECO:0000256|RuleBase:RU362114};
DE Flags: Fragment;
GN Name=TNKS2 {ECO:0000313|EMBL:ETE64991.1};
GN ORFNames=L345_09235 {ECO:0000313|EMBL:ETE64991.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE64991.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE64991.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE64991.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the ARTD/PARP family.
CC {ECO:0000256|ARBA:ARBA00024347}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE64991.1}.
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DR EMBL; AZIM01002026; ETE64991.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NST8; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd09524; SAM_tankyrase1_2; 1.
DR CDD; cd01438; tankyrase_like; 1.
DR Gene3D; 3.90.228.10; -; 1.
DR Gene3D; 6.20.320.10; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 5.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR012317; Poly(ADP-ribose)pol_cat_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF13857; Ank_5; 1.
DR Pfam; PF00644; PARP; 1.
DR Pfam; PF07647; SAM_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 15.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF56399; ADP-ribosylation; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 13.
DR PROSITE; PS50088; ANK_REPEAT; 14.
DR PROSITE; PS51059; PARP_CATALYTIC; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Glycosyltransferase {ECO:0000256|RuleBase:RU362114};
KW NAD {ECO:0000256|RuleBase:RU362114};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|RuleBase:RU362114}.
FT REPEAT 1..28
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 29..61
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 62..94
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 149..181
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 182..214
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 215..247
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 316..348
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 349..381
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 442..474
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 475..507
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 508..540
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 595..627
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 628..660
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 661..693
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 793..852
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 875..1080
FT /note="PARP catalytic"
FT /evidence="ECO:0000259|PROSITE:PS51059"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE64991.1"
SQ SEQUENCE 1082 AA; 117958 MW; 54BA0BA2773E1273 CRC64;
LLFISGFGRR DVVDYLLQSG ANVHARDDGG LIPLHNACSF GHAEVVNLLL RHGADPNARD
NWNYTPLHEA AIKGKIDVCI VLLQHGADPS IRNTDGRTAL DLADPSAKAV LTGEYKKDEL
LESARSGNEE KLMALLTPLN VNCHASDGRK STPLHLAAGY NRVKIVQLLL QHGADVHAKD
KGDLVPLHNA CSYGHYEVTE LLVKHGACVN AMDLWQFTPL HEAASKNRVE VCSLLLSYGA
DPTLLNCHNK STIDLAPTPQ LKERLAYEFK GHSLLQAARE SDVNRHCAAA SPYPKRKQVC
ELLLRKGANI NEKTKDFLTP LHVASEKAHN DVVEVVVKHE AKVNALDNLG QTSLHRAAHC
GHLQTCRLLL SFGCDPSIIS LQGFTASQMG NESVQQLLQE GVPLGNSEAD RQLLEAAKAG
DVDTVKKLCT THSVNCRDIE GRQSTPLHFA AGYNRVSVVE YLLQHGADVH AKDKGGLVPL
HNACSYGHYE VAELLVKHGA VVNVADLWKF TPLHEAAAKG KYEICKLLLQ HGADPTKKNR
DGNTPLDLVK DGDTDIQDLL RGDAALLDAA KKGCLARVKK LCSPDNVNCR DTQGRHSTPL
HLAAGYNNLE VAEYLLQHGA DVNAQDKGGL IPLHNAASYG HVDVAALLIK YNACVNATDK
WAFTPLHEAA QKGRTQLCAL LLAHGADPTL KNQEGQTSLD LVTADDVSAL LAAAMPLSAL
PSCYKPQVIN VSQNTGTSAD ALSSIPSSPS NLSAASSLDS LSGSFSELSV VNTNGAEGAS
SLEKKEVLSV DFSINQFVRN LGLEHLIDIL EREQITLDVL VEMGHRELKE IGINAYGHRH
KIIKGVERLI SGQQGLNSYL TLNTSGSGTI LIDLSPDDKE FQSVEDEMQS TVREHRDGGH
AGGIFNRYNI LKIQKVCNKK LWERYTHRRK EVSEENHNHA NERMLFHGSP FVNAIIHKGF
DERHAYIGGM FGAGIYFAEN SSKSNQYVYG IGGGTGCPIH KDRSCYICHR QLLFCRVTLG
KSFLQFSAMK MAHSPPGHHS VTGRPSVNGL ALAEYVIYRG EQAYPEYLIT YQIVKPEIAT
EA
//
