ID V8NTJ8_OPHHA Unreviewed; 1931 AA.
AC V8NTJ8;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 50.
DE SubName: Full=Dedicator of cytokinesis protein 9 {ECO:0000313|EMBL:ETE65390.1};
DE Flags: Fragment;
GN Name=DOCK9 {ECO:0000313|EMBL:ETE65390.1};
GN ORFNames=L345_08837 {ECO:0000313|EMBL:ETE65390.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65390.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65390.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65390.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65390.1}.
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DR EMBL; AZIM01001904; ETE65390.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF77; DEDICATOR OF CYTOKINESIS PROTEIN 9; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 171..206
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 564..742
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1504..1893
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1171..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65390.1"
SQ SEQUENCE 1931 AA; 221263 MW; 85BD313A26F6175A CRC64;
SPFQAKPKVI EPIDYENVIV QKKTQIINDG LRELLLFPYD DFQTAVLKRQ HQYICSTIPE
NAEKEAYSLF VTECIKTYIS DWHVVNFKHE DYSGDFRQLP NKGNRLEKLP VHVFEVDEEA
DKDEASLFDA ASLGSQKGGL TKQGWLYKGN MNSAISVTMR VCIIFNNKVR RFAFELKMQD
KSSYLLAADS EAEMEEWITT LNKILQLNFE AAMQEKRYED SHEEDEQNRI DSSSGLDAYL
PEIAKSCRDS EFKFKNESRV KLFALDPDAQ KLDFSGIEPE VKPFEEKFGK KILVKCNDLS
FNLQSCVAEN EEGPTTNVEP FFISLSLFDV KHNRKISSDF HVDLNHSTVR HMLANTSQEL
LNGNSDCLHP IQNIISDVIL QYPKQGIFSV TCPHPDIFLV ARIEKVLQGS ITHCAEPYMK
SSDSSKVAQK VLKNAKQACQ RLGQYRMPFA WAARTLFKDM AGTLDKSARF STLYKQDSNK
LSNEDMLKLL ADFRKPEKMS KLPVILGNLD ITIDNVSPEV PNFVNSSYIP MKHFENNSKA
VVTFEVEEFV PCIPKHIQPS TIYNNHLYVY PKHLKYDSQK SFAKARNIAV CIEFRDSDDE
DSRPLKCIYG RPGGPIFTRQ AFVAVLHHQQ NPEFYDEVKI ELPTQLHEKH HLLFTFYHVS
CDSSSKGTTK KKDIIETQVG YSWLQLLKDG RVVTNEQHMP VSAYLPSRYL NSQESGISKH
SSPEIKWVDG GKPLLTISTH LVSTVYTQDQ HLNNFFHYCQ KTMSGAQALG CDLVKYLKSL
HAMEGHVMIA FLPTILNQLF RVLTRATQED VAVNVTRVII HVVAHCHEEG LDSYLRSYVK
YVFKGETYIA SEYKTVHEEL AKTMTTILKP CTDFLTSNKL LKLLRNQRFP ASFHHAVETV
VNMLMPHITQ KYKDNPEASK NANYSLAVFI KQCFTFMDRG FIFKQINNYI SFFAPGDPKA
LFEFKFEFLR AVCNHEHYIP LNLPMPFGTG RIQRYQAFLT VDSYDIPGDL QLDYSLSDDF
CKHHFLVGLL LREVGNALQE FREIRQIAIG VLKNLMIKHS FDDRYALKSH QARIATLYLP
IFGLLIENVH RIDVKDISPF PINAASSGAK DETLNLPAAN PLMTPQKSVN ALDSSLQKDL
FGAISGIAPP YTCSTPNVNY ARNADSRGSL ISTDSGNSLP EKHGEKNNSL DKNQQAYISG
SSVVRCDKLD QAEIRSLLMC FLHVLKSMTD DALFTYWNKA STSELMDFFT ITEVCLHQFQ
YMGKRYIARN QEGLGPIVHD RKSQTLPVSR NRTGMMHARL QQLSSLDNSL SFSHSYGHSE
ADVLHQSLLE ANIATEVGLT ILNTLSLFTV AFKNQLLKDD GHNPLMKKVF DVYICFLQKN
QSETALKNVF NALRTLIFKF PSTFYEGRAD MCSSLCCEIL KCCNSKLSSI RNEASQLLYF
LMKNNFDYTK KRSFVRTHLQ HTTFPSDVKD LTKRIRTVLM ATAQMKEHEN DPEMLVDLQY
SLAKSYASTP ELRKTWLDSM AKIHVKNGDF SEAAMCYVHV AALVAEYLLR KGMFRQGCSS
FRVITPNIDE EASMMEDVGM QGVHFNEEIL MELLEQCADG LWKAERYELI ADIYKLIIPI
YEKRRDFEGF FEDEDGKEYI YKEPKLTSLS EISQRLQKLY SDKFGSENVR MIQDSDKVNP
KDLDSKYAYI QVTHVVPYFE EKELQERKTE FERNHNIRRF MFEMPFTQLG KRRGVVEEQC
KRRIILTVIN CFPYVKKRIP IMYQQYKDLN PIEVAIDEMN KKNAELRQLC SSTEVDMIKL
QLKLQGSVSV QVNAGPLAYA RAFLDDTSTK RYPDNKVKSL KEIFRQFIET CGQALEVNER
LIKEDQIEYQ EEMKANYREM AKELSEIMHE QITAVEEKAN VMSNSLHIFN AISGTATSTT
VHGMPSSSSI A
//
