ID V8NTP0_OPHHA Unreviewed; 919 AA.
AC V8NTP0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE SubName: Full=Folliculin-interacting protein 2 {ECO:0000313|EMBL:ETE65430.1};
DE Flags: Fragment;
GN Name=FNIP2 {ECO:0000313|EMBL:ETE65430.1};
GN ORFNames=L345_08795 {ECO:0000313|EMBL:ETE65430.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65430.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65430.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65430.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the FNIP family.
CC {ECO:0000256|ARBA:ARBA00007541}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65430.1}.
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DR EMBL; AZIM01001887; ETE65430.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NTP0; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR037545; DENN_FNIP1/2.
DR InterPro; IPR028086; FNIP_C_dom.
DR InterPro; IPR026156; FNIP_fam.
DR InterPro; IPR028085; FNIP_mid_dom.
DR InterPro; IPR028084; FNIP_N_dom.
DR PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR Pfam; PF14638; FNIP_C; 1.
DR Pfam; PF14637; FNIP_M; 1.
DR Pfam; PF14636; FNIP_N; 1.
DR PRINTS; PR02073; FOLLICULNIP1.
DR PROSITE; PS51836; DENN_FNIP12; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..910
FT /note="UDENN FNIP1/2-type"
FT /evidence="ECO:0000259|PROSITE:PS51836"
FT REGION 617..637
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65430.1"
SQ SEQUENCE 919 AA; 103008 MW; 0F230B2EC737E24E CRC64;
WSCSGFDLNE IRLIVYQDCE RRGRQVLFDS TAVRKTDEKQ FQYARPASDV NMLGEMMFGS
VAMSYKGSTL KIHYIRSPPQ LMMSKVFSAK VSSFFGSTNS LQGSFEYINQ DQSRLNLHPN
GLGQYQNGNI LAHSTPVDMP NRGQNEDRDS GIAQSASLTS LLMTPLPSPS SSSSYQRRWF
RSQTTSLENG ITPRRSIEET FSMADESCGL NPALIRRKKI AISIIFTLPE KEEAQKNFQD
FFFSHFPLFE SHMGKLKSAI EMAMITCRKI AETNQRVQVY ISRIMDALDE FRTTVWNLYT
VPRIAEPVWL TMMSCASEKN LLCQHFLKEF AVLIEQSSKN QFFAALLTAV LTYHLAWVPT
VMPVDHLSIR VFSEKQASPS VNMLAKSHPY NPLWAQLGDL YGAVGSPVRM TRTVIVGKHK
DFVQRILYVL TYFLRCSELQ ENHLVWNGQL DKGEQAVNGR NIITTLEKGE VEESDYFKTN
LLLYLLSCLQ RMVELLLLLL LLLLLLLLAA AAAAAAAEHE CCFESACFKG NSEASPCFSR
VSPPKRIVGE IKKGKTLVNS EIACGRHGVL EDLTARMDED KHSVTGQLFQ NLVAVPNAKK
IAQVCSQLEK VTFQIGSSTS PESDSETQRM EANKTLEKRR SKTKSLCALS NPLHITPRAP
EEKSNLCLKT CTSQTVGETE TSRAPWLLSV PRSVILDREV KMVNLGKLDE VYSTSCENFE
RNSLDCDSGS STDIQKFCTV STQSMIHFGR SLLGGYCTSY MPDLVLHGIS SDEQLKQHLS
AELSHTIKHP VLDESIAEAV YIIADTDKWT VQVSTSQKKM ADNIKLGKDV LVSSLVSSLL
QSVLQLYKLN LSADFCIMHL EDRLQEMYHK STMLSKYLRG QTRVHVKELG VVLGIESNDL
PLLAAIASTH SPYVAQILL
//