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Database: UniProt
Entry: V8NTP0_OPHHA
LinkDB: V8NTP0_OPHHA
Original site: V8NTP0_OPHHA 
ID   V8NTP0_OPHHA            Unreviewed;       919 AA.
AC   V8NTP0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-FEB-2023, entry version 22.
DE   SubName: Full=Folliculin-interacting protein 2 {ECO:0000313|EMBL:ETE65430.1};
DE   Flags: Fragment;
GN   Name=FNIP2 {ECO:0000313|EMBL:ETE65430.1};
GN   ORFNames=L345_08795 {ECO:0000313|EMBL:ETE65430.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65430.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE65430.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE65430.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004656}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the FNIP family.
CC       {ECO:0000256|ARBA:ARBA00007541}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE65430.1}.
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DR   EMBL; AZIM01001887; ETE65430.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NTP0; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR037545; DENN_FNIP1/2.
DR   InterPro; IPR028086; FNIP_C_dom.
DR   InterPro; IPR026156; FNIP_fam.
DR   InterPro; IPR028085; FNIP_mid_dom.
DR   InterPro; IPR028084; FNIP_N_dom.
DR   PANTHER; PTHR21634:SF11; FOLLICULIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR21634; UNCHARACTERIZED; 1.
DR   Pfam; PF14638; FNIP_C; 1.
DR   Pfam; PF14637; FNIP_M; 1.
DR   Pfam; PF14636; FNIP_N; 1.
DR   PRINTS; PR02073; FOLLICULNIP1.
DR   PROSITE; PS51836; DENN_FNIP12; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        342..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        495..517
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          6..910
FT                   /note="UDENN FNIP1/2-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51836"
FT   REGION          617..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE65430.1"
SQ   SEQUENCE   919 AA;  103008 MW;  0F230B2EC737E24E CRC64;
     WSCSGFDLNE IRLIVYQDCE RRGRQVLFDS TAVRKTDEKQ FQYARPASDV NMLGEMMFGS
     VAMSYKGSTL KIHYIRSPPQ LMMSKVFSAK VSSFFGSTNS LQGSFEYINQ DQSRLNLHPN
     GLGQYQNGNI LAHSTPVDMP NRGQNEDRDS GIAQSASLTS LLMTPLPSPS SSSSYQRRWF
     RSQTTSLENG ITPRRSIEET FSMADESCGL NPALIRRKKI AISIIFTLPE KEEAQKNFQD
     FFFSHFPLFE SHMGKLKSAI EMAMITCRKI AETNQRVQVY ISRIMDALDE FRTTVWNLYT
     VPRIAEPVWL TMMSCASEKN LLCQHFLKEF AVLIEQSSKN QFFAALLTAV LTYHLAWVPT
     VMPVDHLSIR VFSEKQASPS VNMLAKSHPY NPLWAQLGDL YGAVGSPVRM TRTVIVGKHK
     DFVQRILYVL TYFLRCSELQ ENHLVWNGQL DKGEQAVNGR NIITTLEKGE VEESDYFKTN
     LLLYLLSCLQ RMVELLLLLL LLLLLLLLAA AAAAAAAEHE CCFESACFKG NSEASPCFSR
     VSPPKRIVGE IKKGKTLVNS EIACGRHGVL EDLTARMDED KHSVTGQLFQ NLVAVPNAKK
     IAQVCSQLEK VTFQIGSSTS PESDSETQRM EANKTLEKRR SKTKSLCALS NPLHITPRAP
     EEKSNLCLKT CTSQTVGETE TSRAPWLLSV PRSVILDREV KMVNLGKLDE VYSTSCENFE
     RNSLDCDSGS STDIQKFCTV STQSMIHFGR SLLGGYCTSY MPDLVLHGIS SDEQLKQHLS
     AELSHTIKHP VLDESIAEAV YIIADTDKWT VQVSTSQKKM ADNIKLGKDV LVSSLVSSLL
     QSVLQLYKLN LSADFCIMHL EDRLQEMYHK STMLSKYLRG QTRVHVKELG VVLGIESNDL
     PLLAAIASTH SPYVAQILL
//
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