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Database: UniProt
Entry: V8NTW4_OPHHA
LinkDB: V8NTW4_OPHHA
Original site: V8NTW4_OPHHA 
ID   V8NTW4_OPHHA            Unreviewed;      1844 AA.
AC   V8NTW4;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   28-FEB-2018, entry version 22.
DE   SubName: Full=Sodium channel protein type 8 subunit alpha {ECO:0000313|EMBL:ETE65133.1};
DE   Flags: Fragment;
GN   Name=SCN8A {ECO:0000313|EMBL:ETE65133.1};
GN   ORFNames=L345_09096 {ECO:0000313|EMBL:ETE65133.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65133.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE65133.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE65133.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE65133.1}.
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DR   EMBL; AZIM01001981; ETE65133.1; -; Genomic_DNA.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008054; Na_channel_a8su.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR01667; NACHANNEL8.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000018936};
KW   Ion channel {ECO:0000313|EMBL:ETE65133.1};
KW   Ion transport {ECO:0000313|EMBL:ETE65133.1};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:ETE65133.1}.
FT   TRANSMEM    111    134       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    182    202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    237    257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    370    397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    746    764       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    776    794       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    814    835       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    884       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    943    969       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1189   1207       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1228   1247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1259   1282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1303   1331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1428   1454       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1512   1530       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1542   1560       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1572   1592       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1629   1657       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1732   1755       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      116    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      480    693       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      746    973       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      983   1182       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1187   1462       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1511   1763       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      394    432       {ECO:0000256|SAM:Coils}.
FT   COILED      470    490       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE65133.1}.
SQ   SEQUENCE   1844 AA;  210135 MW;  FBB51CFC054FA7C7 CRC64;
     MAGRLLAPPG PDSFRPFTPE SLANIEKRIA EEKKKKRPKQ DSSHRDDDEE NKPKPNSDLE
     AGKSLPFIYG DIPKGLVAVP LEDFDPFYMT QKTFVVLNRG KTLFRFSATP ALYILIFSMI
     IMCTILTNCV FMTFSNPPEW SKQVEYTFTG IYTFESLVKI IARGFCIDGF TFLRDAWNWL
     DFSVIMMAYV TEFVDLGNVS ALRTFRVLRA LKTISVIPGL KTIVGALIQS VKKLSDVMIL
     TVFCLSVFAL IGLQLFMGNL RNKCVIWPID LNETYLENGT KGFDWEEYSN NVSNFYTIPG
     FLDPLLCGNS SDAGQCPEGY TCMKAGRNPN YGYTSFDTFS WAFLALFRLM TQDFWENLYQ
     LTLRAAGKTY MIFFVLVIFV GSFYLVNLIL AVVAMAYEEQ NQATLEEAEQ KEAEFKAMLE
     QLKKQQEEAQ AAAMATSAGT VSEDAVEEDG GGRMSHTSSE FSKLSSKSAK ERRNRRKKRK
     EKELSEGEEK GDIEKVFKSE SEDGMRRKVF RLPDNRLGRK LSIMNQSLLS IPGSPYLSRH
     NSKSSIFSFK RGFRDPGSEN EFADDEHSTV EESEGRRDSL FIPIRGYDRK SSYSGYSGYS
     QGSRSSRIFP SIRRNVKRNS TVDCNGVVSL IGGPTSNIPS GRLLPEVKID KAATDNSATT
     EVEIKKKATG SLLVSMDQLN ASYGRKDRTN SIMTVITNTL VEELEESQRK CPPCWYKFAN
     TFLIWECHPH WVKLKEIVNL IVMDPFVDLA ITICIVLNTL FMAMEHHPMT PQFEHVLAVG
     NLVFTGIFTA EMFLKLIAMD PYYYFQEGWN IFDGFIVSLS LLELMLADVE GLSVLRSFRL
     LRVFKLAKSW PTLNMLIKII GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KNYKECVCKI
     NPDCDLPRWH MHDFFHSFLI VFRVLCGEWI ETMWDCMEVA GQAMCLIVFM MVMVIGNLVV
     LNLFLALLLS SFSADNLAAS DDDGEMNNLQ ISVIRIKKGI AWTKIKVHDF VQTHFKQREA
     DEIKPLDELY DKKMNCIANH TGADINREID YQKNGNGTTS GIGSSVEKYI IDEDHMSFIN
     NPHLTVRVPI AVGESDFENL NTEDFSSDTD GSKEKLDDTS SSEGSTIDIK PEAEEVPVEA
     PEEYLDPDAC FTEGCVQKFK CCQVSIEEGL GKSWWNLRKT CFLIVEHNWF ETFIIFMILL
     SSGALAFEDI YIEQRKTIRT VLEYADKVFT YIFILEMLLK WCAYGFVKFF TNAWCWLDFL
     IVAVSLVSLI ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL VGAIPSIMNV
     LLVCLIFWLI FSIMGVNLFA GKYHYCFNQT AEHRFDIEEV NNKTECEKLM DPNGTEIRWK
     NVKINFDNVG AGYLALLQIA TFKGWMDIMY AAVDSRKQEE QPKYEDNIYM YIYFVIFIIF
     GSFFTLNLFI GVIIDNFNQQ KKKIGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPLNRI
     QGAVFDFVTQ QAFDILIMLL ICLNMVTMMV ETDTQSKQME DILYWINFVF VIFFTCECVL
     KMFALRHYYF TIGWNIFDFV VVILSIVGMF LAEIIEKYFV SPTLFRVIRL ARIGRILRLI
     KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKHEAG IDDMFNFETF
     GNSMICLFQI TTSAGWDGLL LPILNRPPDC DLEKEHPGSG FKGDCGNPSV GIFFFVSYII
     ISFLIVVNMY IAIILENFSV ATEEMVIQRA YRVRLARRGF VCRKNVSNRI ENGGTNREKK
     EGTPSTASLP SYDSVTKPEK EKQRAEEGRR ERAKRQKDVR ESKC
//
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