ID V8NVE0_OPHHA Unreviewed; 1150 AA.
AC V8NVE0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Integrin alpha-6 {ECO:0000313|EMBL:ETE65497.1};
DE Flags: Fragment;
GN Name=ITGA6 {ECO:0000313|EMBL:ETE65497.1};
GN ORFNames=L345_08729 {ECO:0000313|EMBL:ETE65497.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65497.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65497.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65497.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65497.1}.
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DR EMBL; AZIM01001868; ETE65497.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NVE0; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 2.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF9; INTEGRIN ALPHA-6; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 2.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 3.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1071..1095
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 313..374
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 376..431
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 432..493
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 478..547
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 571..683
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 685..850
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 856..1061
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 647..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1121..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1129..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65497.1"
SQ SEQUENCE 1150 AA; 128700 MW; 49F24107E12CA2CF CRC64;
MVNGVDCVYL VSLLSNLFPI TFFWSSFHSL LVGAPRQKAF PLQQANRTGG LFSCDIETPE
VPCTRIKFDE TADPAKESKE DQWMGVTVRS QGPGGKIVTC AHRYEKRYYV NTDQETRDII
GRCYVLSQDL SISGNEYMDG GEWSFCDGRL RGHEKFGSCQ QGVAATFTRD NHYIVFGAPG
TYNWKGVVRA EQRNHTLDEM GIFDDGPYEV GGESLRKESL VPVPANSYLG LLFMTSVSYA
NPDQFVYKTL PPSVRVDKPA DLMMNSYLGF SLDSGKGIIS QEEITFVSGA PRANHSGAVV
LLKKDSDIQR ALSSVHIFEG EGLASSFGYD VAVVDLNSDG WQDIVVGAPQ YFEKDGEIGG
AAYVYINQEG KWDKVNPIRL NGTKDSMFGI AVENIGDVNK DGFPDIAVGA PYAKEFGKVY
LYHGSRNGIN TKPAQILEGE KNVPFFGYSI TGNMDLDGNS YPDIAVGSLS DTVSVYRSRP
VISIKKSLMI SPDKIDLNMQ NCEVSSKLWT TDNIELSKMC LRVQYKRKDS QKEINLVFQL
NLKKEKEANL DCPVWIFWMC LGSQLPEFGL LILDYTFEAD HERKKSGLLP RVHFTKPHSV
PFSGSVILKR QKMEECVTSR LELEEKIKDK LRPIPVSLKI ALHTPESSVK PRRRQGRSLP
DLTPILNADE PDTMHSEVQF LKEGCGSDNI CHSNLNMHYR FCTKEGNEDK FAYFPMENNV
PVLILKDQKE IALEITVTNN PSSAVHPLKD GEDAHEAKLV ATFPDSLTYS TYREWKSFPE
KLVSCGANPN GSQVDCELGN PFKRNSTVTF YVILSTTKVN VDTKELDINL KLETTSNQTN
LKPITAKAKV VIELLLSLTG VAKPSQVYFG GNIIGESAMK SEHEIGSLIE YEFRITNLGK
PLKTFGTAFL EIMWPKELRG GKWLLYLVSI HSKELGELQC SPQNEINLLK VQRSQNARIK
REVAEKQTEG SQSFSLFRER KYKTLECNEE ANCVNITCSL QGLDSKAVVV LRSRLWNSTF
LEEFYKMSYL DIFVRARIGI SAADNVKLAN EATTVRVNVF PTKTVALYKE VPWWIILVAI
LAGLLMLALL VFLLWKCGFF KRDKKDHFDA TYHKAEIHAQ PSDKERLTSD AYAGSSSVPG
TMTASPATML
//
