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Database: UniProt
Entry: V8NVR0_OPHHA
LinkDB: V8NVR0_OPHHA
Original site: V8NVR0_OPHHA 
ID   V8NVR0_OPHHA            Unreviewed;       983 AA.
AC   V8NVR0;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   22-FEB-2023, entry version 45.
DE   SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|EMBL:ETE65773.1};
DE   Flags: Fragment;
GN   Name=RASGRF2 {ECO:0000313|EMBL:ETE65773.1};
GN   ORFNames=L345_08453 {ECO:0000313|EMBL:ETE65773.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65773.1, ECO:0000313|Proteomes:UP000018936};
RN   [1] {ECO:0000313|EMBL:ETE65773.1, ECO:0000313|Proteomes:UP000018936}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE65773.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA   Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT   snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETE65773.1}.
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DR   EMBL; AZIM01001786; ETE65773.1; -; Genomic_DNA.
DR   AlphaFoldDB; V8NVR0; -.
DR   Proteomes; UP000018936; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 2.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT   DOMAIN          1..179
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          381..497
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          748..980
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          459..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..556
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          577..603
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..553
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETE65773.1"
SQ   SEQUENCE   983 AA;  111998 MW;  0B21ADAF8AD58748 CRC64;
     MVEAESEYVH QVYILVNCFL RPLRMAASSK KPPISHDDVS SIFLNSETIM FLHEIFHQGL
     KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD KLLKQYESNT
     ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE ELSRIMHDEV
     SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGTLIQVP SVERGKLSKV RLGSLSLKKE
     GERQCFLFTK HFLICTRSSG GKLHLLKVHI FIAKIMTRIM NCRTYTKGSG QVFGHLDFKI
     VVDPAGAPPF TVVLLAPSRQ EKAAWTSDIS QCVDNIRCNG LMTIVFEENS KVTVPHMIKS
     DARLHKDDID ICFSKTLNSC KVPQIRYASV ERLLERLTDL RFLSIDFLNT FLHTYRIFTN
     ATVVLEKLSD IYKRPFTSIP VRSLELFFAT NQNNREHMAD AKSPHLCRKF SSPPPLSLSR
     TSSPVRTRKL SLNSPLNSRI GALDLSASSV SSPTSTYSPG TSPPMSTKVP LDLSKSPSSP
     EQSPVFSEDN SENPRNELCN KLRRSIRRAG VLESVPVDHP IPESASTVDP PELSPCRSPS
     TPRHLRFRQT GVQVTDNGHC SVSPASAFAI ATAAAGHGSP PAFNNSERTC DKEFIIRRAA
     TNRVLNVLRH WVSKHSQDFE LNNELKMSVL NLLEEVLRDP DLLPQERKAT ANILRTLSQE
     DQDDTHLKIE DIMQMLECPK PECFETLSAM ELAEQITLLD HIVFRGIPYE EFLGQGWMKL
     DKNERTPYIM KTSQHFNDMS NLVASQIMNY TDIGSRANAI EKWVAVADIC RCLHNYNGVL
     EITSALNRSA IYRLKKTWAK VSKQTKALMD KLQKIVSSEG RFKNLRETLK NCNPPSVPYL
     GMYLTDLAFI EEGTPNFTEE GLVNFSKMRM ISHIIREIRQ FQQASYRIEH QQKVTQYLLD
     KSLIIDEDTL YELSLKIEPR LPA
//
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