ID V8NVR0_OPHHA Unreviewed; 983 AA.
AC V8NVR0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 45.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|EMBL:ETE65773.1};
DE Flags: Fragment;
GN Name=RASGRF2 {ECO:0000313|EMBL:ETE65773.1};
GN ORFNames=L345_08453 {ECO:0000313|EMBL:ETE65773.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE65773.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE65773.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE65773.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE65773.1}.
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DR EMBL; AZIM01001786; ETE65773.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NVR0; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 1..179
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 381..497
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 748..980
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 459..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 507..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE65773.1"
SQ SEQUENCE 983 AA; 111998 MW; 0B21ADAF8AD58748 CRC64;
MVEAESEYVH QVYILVNCFL RPLRMAASSK KPPISHDDVS SIFLNSETIM FLHEIFHQGL
KARIANWPTL ILADLFDILL PMLNIYQEFV RNHQYSLQVL ANCKQNRDFD KLLKQYESNT
ACEGRMLETF LTYPMFQIPR YIITLHELLA HTPHEHVERK SLEFAKSKLE ELSRIMHDEV
SDTENIRKNL AIERMIVEGC DILLDTSQTF IRQGTLIQVP SVERGKLSKV RLGSLSLKKE
GERQCFLFTK HFLICTRSSG GKLHLLKVHI FIAKIMTRIM NCRTYTKGSG QVFGHLDFKI
VVDPAGAPPF TVVLLAPSRQ EKAAWTSDIS QCVDNIRCNG LMTIVFEENS KVTVPHMIKS
DARLHKDDID ICFSKTLNSC KVPQIRYASV ERLLERLTDL RFLSIDFLNT FLHTYRIFTN
ATVVLEKLSD IYKRPFTSIP VRSLELFFAT NQNNREHMAD AKSPHLCRKF SSPPPLSLSR
TSSPVRTRKL SLNSPLNSRI GALDLSASSV SSPTSTYSPG TSPPMSTKVP LDLSKSPSSP
EQSPVFSEDN SENPRNELCN KLRRSIRRAG VLESVPVDHP IPESASTVDP PELSPCRSPS
TPRHLRFRQT GVQVTDNGHC SVSPASAFAI ATAAAGHGSP PAFNNSERTC DKEFIIRRAA
TNRVLNVLRH WVSKHSQDFE LNNELKMSVL NLLEEVLRDP DLLPQERKAT ANILRTLSQE
DQDDTHLKIE DIMQMLECPK PECFETLSAM ELAEQITLLD HIVFRGIPYE EFLGQGWMKL
DKNERTPYIM KTSQHFNDMS NLVASQIMNY TDIGSRANAI EKWVAVADIC RCLHNYNGVL
EITSALNRSA IYRLKKTWAK VSKQTKALMD KLQKIVSSEG RFKNLRETLK NCNPPSVPYL
GMYLTDLAFI EEGTPNFTEE GLVNFSKMRM ISHIIREIRQ FQQASYRIEH QQKVTQYLLD
KSLIIDEDTL YELSLKIEPR LPA
//