ID V8NYI4_OPHHA Unreviewed; 492 AA.
AC V8NYI4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE SubName: Full=Glial cell line-derived neurotrophic factor {ECO:0000313|EMBL:ETE67324.1};
DE Flags: Fragment;
GN Name=GDNF {ECO:0000313|EMBL:ETE67324.1};
GN ORFNames=L345_06887 {ECO:0000313|EMBL:ETE67324.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67324.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67324.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67324.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67324.1}.
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DR EMBL; AZIM01001325; ETE67324.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NYI4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR008795; Prominin.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR PANTHER; PTHR12173:SF1; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; 1.
DR Pfam; PF05478; Prominin; 2.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..492
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004771125"
FT DOMAIN 93..218
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 22..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 224..265
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 86..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 492
FT /evidence="ECO:0000313|EMBL:ETE67324.1"
SQ SEQUENCE 492 AA; 55632 MW; F518109925E72EC2 CRC64;
MNLWDLVTVC LVLLNSISTF PLPAGKRPPE KARSVLGRAE EDHTTSRLLN PYAGQMDSNI
LVDYPSQLED VMDFIQTTLK RLKRSPDKPL FSKRERNRQN AGRNNNSNKR KGQRAQRLKS
RDCVLSEIHL NVTDLGLGYT TKEELIFRYC SGSCETAVTL YDQILNNLTQ NKKLVSDKIR
PQPCCRPIAY DDDVSFLDDD LSTYHILRKH SAKKCGWSPI SINIQRIDQE LQQVNQTGDR
LQKMQQELIK NLTDLRTKIN DTLKECGSPC GEISAENMIP EANFDTIPDV SDPLNLISNL
TSLDLNSTVI KSLAAAVSAS GEEKIQLEES YLDTSGLFPE LNVKKLMNLN GSDVNLTSIY
KSCEEDAPLW STLHLDEIVS LNDTFNISKY TQNIDSTLNK IKINIGTIEL LNDEQKHSLL
KLSAKDGPLN VDFNSTLEQL NQNLTKQDLN ILANKLEEVA DTTTNDTREN LKHQANELKK
IQEWINVKFP PE
//
