ID V8NYS4_OPHHA Unreviewed; 494 AA.
AC V8NYS4;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=5'-nucleotidase domain-containing protein 2 {ECO:0000313|EMBL:ETE67404.1};
DE Flags: Fragment;
GN Name=Nt5dc2 {ECO:0000313|EMBL:ETE67404.1};
GN ORFNames=L345_06821 {ECO:0000313|EMBL:ETE67404.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67404.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67404.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67404.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC {ECO:0000256|ARBA:ARBA00009589}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67404.1}.
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DR EMBL; AZIM01001307; ETE67404.1; -; Genomic_DNA.
DR AlphaFoldDB; V8NYS4; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR InterPro; IPR023214; HAD_sf.
DR PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR12103:SF19; 5'-NUCLEOTIDASE DOMAIN-CONTAINING 2; 1.
DR Pfam; PF05761; 5_nucleotid; 2.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT REGION 33..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE67404.1"
SQ SEQUENCE 494 AA; 56875 MW; 42B84F38433F6FA0 CRC64;
MAGAAVRAGR FVRLAAPSLS YCTRFGAEVP AAAAQAPQPS PPYGSRKPRA QRVPADEDPA
ARAFSSAPAP GPDNKSFLWA RYGEMKRLVQ DLLPPGVCNL LNPSTIYANN EISLNTIGVY
GFDYDYTLAL YSPALHSRIY NTARDILVEQ YKYPKGILKY EYWPNFAVRG LHYDIAKGLL
MKIDAFHYIQ LGTGPAVKQF MDIFSLPEMT LLAVANDFFI SNDIDYDPIH LYKDVTKLFL
ITNSPFSFVD KGMRYMVGKD WRDFFDVVIV QADKPHFFND CVKPFRRLDS NGDLQWDKIN
KLEKGQVYKQ GNLFDFLRLT GWRGSKVLYF GDHLYSDLAD LMLRHGWRTG AIVPELETET
KMVNTEQYSQ ALTWLQALTG LLERMQMFQD SESQQVLQDW MKERQELRAL TKNLFNPQFG
SIFRTCHNPT YFSRRLCRFS DVYMASLSCL LNYDLNYTFY PRRTPLQHEA PLWMDQLCTG
CMKTPFLEEM AHIR
//
