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Database: UniProt
Entry: V8NZD2_OPHHA
LinkDB: V8NZD2_OPHHA
Original site: V8NZD2_OPHHA 
ID   V8NZD2_OPHHA            Unreviewed;       931 AA.
AC   V8NZD2;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUN-2019, entry version 29.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 8 {ECO:0000313|EMBL:ETE67609.1};
DE   Flags: Fragment;
GN   Name=ADAMTS8 {ECO:0000313|EMBL:ETE67609.1};
GN   ORFNames=L345_06602 {ECO:0000313|EMBL:ETE67609.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67609.1};
RN   [1] {ECO:0000313|EMBL:ETE67609.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE67609.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE67609.1}.
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DR   EMBL; AZIM01001237; ETE67609.1; -; Genomic_DNA.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR013277; Pept_M12B_ADAM-TS8.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01861; ADAMTS8.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Integrin {ECO:0000313|EMBL:ETE67609.1};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     31       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        32    931       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004772190.
FT   DOMAIN      202    390       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   REGION      150    191       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8NZD2}.
FT   COMPBIAS    152    167       Polar. {ECO:0000256|MobiDB-lite:V8NZD2}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE67609.1}.
FT   NON_TER     931    931       {ECO:0000313|EMBL:ETE67609.1}.
SQ   SEQUENCE   931 AA;  102859 MW;  332BDFEE8AF05C21 CRC64;
     MPLPLQQQSR TSWLAALFSL FPLLLFQNAW ALSLQNRDGV QEVVPVWGDM PRVRGRPVSF
     SITAFGKVLL LQLEPDASFL APGLKIQHVG RKEPVGFLAE KKEEEDVKLR KCFYSGTVNS
     QPDSLVAVSL CEGIHGSFFV DGDKYVIQPQ NRGSGDPLTQ VHQLQKRSSS KEAAKGRRGG
     EAQLDPNSTP FNRAKRFSSQ ARYVETLLVA DTSMVQFYGP DLTNHILTLM SVAAQIYKHP
     SLKNSINLVV VKVLVVEDEK DGPEVSDNGG LMLRNFCNWQ QFFNPPSDRH PEHYDTAILL
     TRQDFCGHQT CRTLGVAETG TMCDPNKSCS VIEDEGLQAA YTLAHELGKH HMMAPLFVHL
     NKTLPWSPCS AMYITEFLDG GHGNCLLDEP AQPIALPTDL PGQIPLYNLD QQCQQIFGKE
     FQHCPNATQE DVCSQLWCKL ETGEQLCHTK NGSLPWADGT PCGPGKMCLE SHCVAQNTVM
     PKLAVDGNWG PWSLWGPCSR TCGGGVHFSY RDCDSPVPKN GGKYYKSFRE HQCEKYDRYN
     FTDLNGNFLE WVPMYAGVSP RDRCKLVCRA KRGNEFKVFE TKVIDGTTCA PDTLSLCVHG
     QCIKAGCDHI IGSSKKLDKC GVCGGDCSTC RKISGSLNKS KFGYNDVVTI PAGATNIDIK
     QHSRRGVRHD GNYLALQTLD GKYLLNGNFT VSAMEQDIFV KGTVLRYSGS LTTLERLQSY
     QQLPESIVVQ VLTVSSEMFL PKAFPPPKVK YTFFIPKDLQ FSKQKIKEKS LANMIKPLLT
     SQWVLGDWSE CSKSCSSGWQ RRTVECLDVE GQPSSTCDKA LKPEDIKPCS GLPCPIWQMG
     PWSPCSQTCG EGMRTQSALC IDYLGKPVAF EKCNSSQPPA ASTLCVLQEC CCSCDAEAIS
     MNAVVCTLQL AKQLQSLGRA GVQNSTFDIG N
//
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