ID V8NZF3_OPHHA Unreviewed; 1336 AA.
AC V8NZF3;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Putative ATP-dependent RNA helicase DHX57 {ECO:0000313|EMBL:ETE67028.1};
DE Flags: Fragment;
GN Name=DHX57 {ECO:0000313|EMBL:ETE67028.1};
GN ORFNames=L345_07176 {ECO:0000313|EMBL:ETE67028.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67028.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67028.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67028.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67028.1}.
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DR EMBL; AZIM01001409; ETE67028.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd17985; DEXHc_DHX57; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR CDD; cd14317; UBA_DHX57; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR042615; DHX57_UBA.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006575; RWD_dom.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF256; ATP-DEPENDENT RNA HELICASE DHX57-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF05773; RWD; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ETE67028.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ETE67028.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 158..202
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 283..310
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 515..682
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 786..959
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT ZN_FING 283..310
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE67028.1"
SQ SEQUENCE 1336 AA; 150336 MW; B5AC9A29EBB2621A CRC64;
MSSSKRRGRP KSRGGKGGGS GSKHQGSGSK HQGSGSKHQG SGSKHQSSGS KKGLDEMWDD
DFCVFGETDD AYRGNGQTKH ASKIKTPLHT LHMTSENQKR VKELLCELQG QELASGSKTV
MSGIADCSES DDEQSWSDDN AFSKTNSRAA SQATVNHVLE TEVSSFAVHK LSRYGFDSEH
CQAVLKSYNG NIGASLEHLL LQCFTEKFGK RMQLTEASVQ ANIKDCFEQR QEEALALRSI
CGDKFVERIQ NRVWTITLEL TYLTNILSKT KQGNSITSNI VNTNSPGICK YYLRGDCKFG
SRCKFKHETS HNEKSLPPIR EDAHLKLNAP VYELEVRFPE ENKYPYQPPL VAFYSTNENL
PLSCRLHLAE FLYEKALISS EFNKPVVYDF VTCLRDEAQV LKLLNKTSHK YSVPPVPPKQ
KFPSSCNNPY QTSVVEAEED EYDQGGLQTV NIEKESYVNL KTKLLLKSST PSEPITKENL
KICKQFSIKK SSRRYQTMLQ ERQKLPAWEE KNNILHLLSK YQVLVVSGMT GCGKTTQVPQ
FILDSSLEGP SNKVANIVCT QPRRIAAISV AERVAKERTE RVGITVGYQI RLESVMSSAT
RLLYCTTGVL LRRLEGDKKL QGITHIIIDE IHERTEESDF LLLIMKDLML QRPELRVVLM
SATLNSNIFS QYFNSCPIVN IPGSTFPVEQ FFLEDAIAMT GYVLEHSSPY MRREKPTAHK
TGRHTRTAAE EVEETLKYTG LVKITLQDSA PDQTLTFQQL LIRYKGVSKS VLKTMANMDL
DKVNLELIEA LLEWIVSGKH LYPPGLAEIQ ALYNRLQSNA MFNNRHSKRC VVYRLHSTLS
SEDQQSVFFQ PPLGITKIII STNIAETSIT INDVVYVIDS GKMKEKRYDP SKGMESLEDS
YVSKANALQR KGRAGRVASG VCFHLFSSHH YNHHLLKHQL PEIQRVPLEQ LCLRIKILEM
FSTHKLQSVL SQLIEPPTAE SINASKKRLQ DVGALTSEEK LTPLGHHLAS LPVDVRIGKL
MLLGTIFRCL DPALTIAASR AHKSPFISPW DKREVAFKKK LEFSIGNSDY LALIQAYKGW
RQSSKESFQA SSAFCRENFL SENVLQEMAR LKRQFTELLS DIGFVKEGLR ARDIEQRFSQ
RGDGVLEATG EEANANAENV KLISAILCAA MYPNVVQIKV PEKKCLKIIK GATKINPKPE
ALMFATKSQG YVHIHPSSVN YQIKQFDSPY LVYHEMVKTS RIFIRDCSMV SVYPLILFGG
GRVNMQLQNG AYVVSLDDGW INFVAASRQV AELVKELRNE LDQLLQEKIK NPSMDLCTCP
RGSRIISLIV KLVTTQ
//
