ID V8NZY0_OPHHA Unreviewed; 1952 AA.
AC V8NZY0;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=Ankyrin repeat domain-containing protein 12 {ECO:0000313|EMBL:ETE67819.1};
GN Name=ANKRD12 {ECO:0000313|EMBL:ETE67819.1};
GN ORFNames=L345_06391 {ECO:0000313|EMBL:ETE67819.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67819.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67819.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67819.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67819.1}.
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DR EMBL; AZIM01001175; ETE67819.1; -; Genomic_DNA.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24149; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR24149:SF16; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT REPEAT 127..159
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 160..192
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 193..225
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 729..986
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1275..1317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..335
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..436
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..584
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 729..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 900..986
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1952 AA; 223842 MW; 06344D0F86394399 CRC64;
MKRKLQFNVS PSRNEDRNSD TDSDPGHTNE NWGERLIPSS RTYSEKEVPE KKKMKKEAGN
KKTAPVSILF GYPLSERKQM ALLMQMTARD NSPDPNLNHP LQTVTTQKKT PSSSSRQKDK
VNKRNERGET PLHTAAIRGD VKQVKELISL GANVNVKDFA GWTPLHEACN AGYYDVAKVL
IAAGADVNTQ GLDDDTPLHD SASSGHRKIV KLLLRHGGNP FQANKHGERP VDVAETEELE
LLLKREVPIS DDEDGCSDLD EAPSVNPSSI EGNMDSETEK ESLANDNKHV SSKTSLPSAL
DEYEFKDDDD EEVKKMIDDR QIPRKDLRKE DMSETEQSNV FLSQEKLSFP KSFKNKKQKP
SRVLYSSSES SDEDILQDKK LISPSCTVTE ISNSDAKSKK EYVYNECKQK GKVKRKLKNQ
SKNKENQQLK QEKDHSKLTN LSVSLLESLD KSKEDDNFRK TFSPKEDASL SLLHITPTRS
PKHPCGINEK QSSTFKQENV KICLSPEGSE VTSQSELIRY DHNADTDFLL ENSSNKSYKN
RDKSKHQKEF ILEFSEKSSP KLKDEDNSPI FENSDIVMKK TDKEGKMLKK HKLKHKEKDR
DKHKKEQDGE KERCKHKENS KDVQRNVEFD REFWKENFFK SDEAEDTSTV DHDPQMSEKK
SKLEKILIKE DKYVKERSFQ KDKNFKEEKE REKTKKENDK EEKTKDHSIF LDKEADFFSL
GVRDMSTNIT VIDKEDIDKQ EKKDHREKNE KRNSSVEKIE RKNTDKEKKI KCEHKSEKDK
PESLENNEKT KEKEKAYVQQ VEKTNKEHDK LKSFNAIKKV DDKEKIKERF EKKHDKEKND
RYFSESKEKS SNDKKCKSSE KDSEYSKMEK GRNKEKEMEK KEKLKERDSS VITNTKQTAE
EKKCSSEKTL FLKEKPKDEL LKTPDGREKD KKDKDIDRYK ERDKYKDKMQ QNNVSKLKSE
TEKLKSKPLP ASKDTRPKEK RLLNDDLMQT SFERMLSLKD LEIEQWHRKH KEKIKQKEKE
RLKNRSCTEL NKIKDKDKIK YSLTDSKNKE LIRSKSSELS DASGKDKQLK DATSSRSQSV
DIKNSNAKPS LALDSSLSRS PRSESEKTGL TSRSISMISI ASSEDSCHTT VTPPRPVVEY
DSDFMLEGSD SQMSFSHSPF LPSAKSPANY ENDSLSELPE RNKALTLNRL PPAYIRSASV
EDVKFVINDC RPVVEVRRCS MPAVYENTKQ SRVPEESNHN TLLSVQSYNT FPKNECCNLL
EKDSQNGLTS LYSSSALSPS RPVHKPNAID AVGKNAAPSS SSGESHTYLE HHNTTPSSKT
WDVPLDRFIS LNSECSCSDY SGCELDATNA SAITNFENKT MKEQKSSESF YHHAENVSNP
TSQEMAEFLS VQSCCPSQIQ PSTDTVYMSK HVALSDTNSQ ELLIKNPQNS IQPSNSVLDI
DASKKKIEKN IILSNNKKAD MLITVYPENI TKDITQNFEK DFVANDPRLH SSANPSAVSK
LIYKTSQAEE LDTSVIDIQF QGEKAHSIDI CSSHMAGNKN DLDLQELNGR TLKGITNEYN
RNFFNMDSAE NTSMEERQQY LPPNLESHSQ LTGHEVHKYS PTIKLELEEA IEDPKAHYEI
PQRITRNRAN ILANQSKQNL SGCSQISERD FDSSASLKGR IRLTEEDDAQ PHHPRKRKLS
RVPQPVQINA SLMQAKEKTH QSLAAVVDSL KLEEIQPYSS ERANPYFEYL HIRKKIEEKR
KLLCSVIPQA PQYYDEYVTF NGSYLLDGNP LSKICIPTIT PPPSLSDPLK ELFKQQEVVR
MKLRLQHSIE REKLIVSNEQ EVLRVHYRAA RTLANQTLPF SACTVLLDAE VYNVPLDAQT
DDSKASVRDR FNARQFMSWL QDVDDKFDKL KTCLLMRQQH EAAALNAVQR LEWQLKLQEL
DPATYKSVSI YEIQEFYVPL VDVNDDFELT PI
//
