ID V8P001_OPHHA Unreviewed; 1015 AA.
AC V8P001;
DT 19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT 19-FEB-2014, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Neuronal-specific septin-3 {ECO:0000256|ARBA:ARBA00041105};
DE Flags: Fragment;
GN Name=Sept3 {ECO:0000313|EMBL:ETE67253.1};
GN ORFNames=L345_06953 {ECO:0000313|EMBL:ETE67253.1};
OS Ophiophagus hannah (King cobra) (Naja hannah).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67253.1, ECO:0000313|Proteomes:UP000018936};
RN [1] {ECO:0000313|EMBL:ETE67253.1, ECO:0000313|Proteomes:UP000018936}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:ETE67253.1};
RX PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W., Dirks R.P.,
RA Spaink H.P., Duboule D., McGlinn E., Kini R.M., Richardson M.K.;
RT "The king cobra genome reveals dynamic gene evolution and adaptation in the
RT snake venom system.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|RuleBase:RU004560}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETE67253.1}.
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DR EMBL; AZIM01001344; ETE67253.1; -; Genomic_DNA.
DR AlphaFoldDB; V8P001; -.
DR Proteomes; UP000018936; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR CDD; cd13214; PH-GRAM_WBP2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR InterPro; IPR008114; Septin3.
DR PANTHER; PTHR18884:SF62; NEURONAL-SPECIFIC SEPTIN-3; 1.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF00735; Septin; 1.
DR PRINTS; PR01741; SEPTIN3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000018936}.
FT DOMAIN 359..629
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT REGION 65..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 948..1015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1015
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ETE67253.1"
SQ SEQUENCE 1015 AA; 112442 MW; A9CBF004A85D16EE CRC64;
MMDKGCTPSP HRIRRCIPVL GASSHCNSIP GCSARSPGTG GLGSVNPSLK KNSLFMQGSP
KQTLLAKGKG IPRPPSRLLS PKSPGTHDVQ VSCPPPTRYQ PLQQTATNGL EQQKLSSISF
TFHQSNSISP TSRQVIWHPM ARKEFQKVSS KEETPGRFKK QPLPPPQLLS GPQTLPESTV
EFISDPQTNS SLENAIQISE TETQDSVKKV GFDSFLSCQA PTRTMGKDLM NYILVKTVHE
AQVSMARNGI PRVKLQSLSG PVKILPPFPQ ECPEEQADMD HYFMKNPTTI SVVNATETEY
KSQNGSADTK SEAVMSELVP EPRQKPVVPM KPVSINSNLL GYIGIDTIIE QMRKKTMKTG
FDFNIMVVGQ SGLGKSTLVN TLFKSQVSRK SSGWNREEKI PKTVEIKAIG HECGVKMKLT
VIDTPGFGDQ INNENCWEPI EKYINEQYEK FLKEEVNIAR KKRIPDTRVH CCLYFISPTG
HSLRPLDMEF MKHLSKMVNI IPVIAKADTM TLEEKIEFKQ RVRKELEVNG IEFYPQKEFD
EDLEDKTEND KIRQESMPFA VVGSDKEYQV NGKRVLGRKT PWGVIEVENL NHCEFALLRD
FVIRTHLQDL KEVTHNIHYE TYRAKRLNDN GGLPPVTNQF SRFQSRTVVA PPRLLQPSQV
TRRRPPRDRL PHSRPAATPP LHREAGLRAR RSRPLRGGSA VFGKGRKRRT ASVGAIGREH
GAEQEPLARW RGCPAPRGKS RHPRDFDSCI LKHCKDVELT FSEITGNPEM FKGTKKGMVF
LTPYRVIFVS KSKDPMMSFM MPFHLVKGCS IEQPVFSANY IKGVIQAEPG GGWEGQASFK
MSFFSGGAVE FGQMMFKLAS DASRGVPPPS FGYGYAPPPF SGAYGPPPGS YVMPQPASGA
YVYMPAQMNG YGVAPQPMGY PYAPPPGAYP PPPGMNSMYM APPPPYPGPS GAGPSAPIDP
GPTAPRTWAE PGMPGGNKAA EATSSAYYNP ANPHNVYMPM DQPPPYAPPE EKKNN
//
