GenomeNet

Database: UniProt
Entry: V8P032_OPHHA
LinkDB: V8P032_OPHHA
Original site: V8P032_OPHHA 
ID   V8P032_OPHHA            Unreviewed;       962 AA.
AC   V8P032;
DT   19-FEB-2014, integrated into UniProtKB/TrEMBL.
DT   19-FEB-2014, sequence version 1.
DT   05-JUN-2019, entry version 29.
DE   SubName: Full=A disintegrin and metalloproteinase with thrombospondin motifs 1 {ECO:0000313|EMBL:ETE67283.1};
DE   Flags: Fragment;
GN   Name=ADAMTS1 {ECO:0000313|EMBL:ETE67283.1};
GN   ORFNames=L345_06929 {ECO:0000313|EMBL:ETE67283.1};
OS   Ophiophagus hannah (King cobra) (Naja hannah).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus.
OX   NCBI_TaxID=8665 {ECO:0000313|EMBL:ETE67283.1};
RN   [1] {ECO:0000313|EMBL:ETE67283.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Blood {ECO:0000313|EMBL:ETE67283.1};
RX   PubMed=24297900; DOI=10.1073/pnas.1314702110;
RA   Vonk F.J., Casewell N.R., Henkel C.V., Heimberg A.M., Jansen H.J.,
RA   McCleary R.J., Kerkkamp H.M., Vos R.A., Guerreiro I., Calvete J.J.,
RA   Wuster W., Woods A.E., Logan J.M., Harrison R.A., Castoe T.A.,
RA   de Koning A.P., Pollock D.D., Yandell M., Calderon D., Renjifo C.,
RA   Currier R.B., Salgado D., Pla D., Sanz L., Hyder A.S., Ribeiro J.M.,
RA   Arntzen J.W., van den Thillart G.E., Boetzer M., Pirovano W.,
RA   Dirks R.P., Spaink H.P., Duboule D., McGlinn E., Kini R.M.,
RA   Richardson M.K.;
RT   "The king cobra genome reveals dynamic gene evolution and adaptation
RT   in the snake venom system.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:20651-20656(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ETE67283.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AZIM01001335; ETE67283.1; -; Genomic_DNA.
DR   GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.20.100.10; -; 3.
DR   Gene3D; 3.40.390.10; -; 1.
DR   InterPro; IPR041645; ADAM_CR_2.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR010294; ADAM_spacer1.
DR   InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR013274; Pept_M12B_ADAM-TS1.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   Pfam; PF17771; ADAM_CR_2; 1.
DR   Pfam; PF05986; ADAM_spacer1; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   Pfam; PF00090; TSP_1; 3.
DR   PRINTS; PR01858; ADAMTS1.
DR   PRINTS; PR01857; ADAMTSFAMILY.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00209; TSP1; 3.
DR   SUPFAM; SSF82895; SSF82895; 3.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50092; TSP1; 3.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00117091};
KW   Integrin {ECO:0000313|EMBL:ETE67283.1};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    962       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004772217.
FT   DOMAIN      242    451       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   REGION      161    202       Disordered. {ECO:0000256|MobiDB-lite:
FT                                V8P032}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:ETE67283.1}.
SQ   SEQUENCE   962 AA;  105732 MW;  0B0D09C7CB40B97D CRC64;
     MKGAKACLAL STLLLSLGAR GGPSSPQEEE LVVPVKVDTG GRRRAADEQF YRLDAFGERF
     SLELKPDGSF LAPALTFQYV GSRPQGRREE EESHQALGAN LASCFYSGTV NGDPASAAAL
     SLCGGIRGAF YLRGSEYLIQ PANVSQAPGG EQPQLHLLSR SRQSRGPEPV VLSARCPTPT
     KVRTPKGGGT TEEKSSRRTT RPAQVLLAPH LSLHRPCPSK ELSSGSSKNR HIRKKRFVSS
     PRYVETLLVA DQSMAEFHDS GLKHYLLTLL SVASRMYKHP SIRNPINLVV VKIIVIYDEQ
     KGPDVSSNAA LTLRNFCSWQ KQHNPPSDRH AEHYDTAILF TRQDLCGAKT CDTLGMADVG
     TACDPNRSCS VIEDDGLQAA FTTTHELGHV FNMPHDDAKQ CTSINGINRD SHMMASMLSN
     LDRNHPWSPC SAYMITTFLD NGHGECLLDK PHKPLPFPSD LPGTMYDANR QCQFTFGEES
     KHCPDFASIC TTLWCTGTSG GLLMCQTKHF PWADGTTCGE GKWCMNGKCV NKTDKKLYDI
     PVHGGWGSWE AWGECSRTCG GGVQYSVREC DSPVPKNGGK YCEGKRVQYR SCNIEDCPEN
     SKTFREEQCE AHNDISKSFG TGLAVEWIPK FAGVSPKDRC KLICLAKGTG YFFVLQPKVV
     DGTLCSPDST SICVQGQCIK AGCDRVIGSS KKFDKCGICG GNGSTCKKVS GMFSNVRPGY
     HDVAVIPAGA TNIEVKQRNH RGTWQDGSFL AIKVADDTYI LNGDYTLTTM EQDITYKGNV
     LRYSGSSASL ERIRSFSPLK EPLTIQVLTV GDSFRSKIKY TYFMKKSTQL GSEEPISKTE
     SFNAIKETVL SEWIIEEWGE CSKSCGTGWQ RRSVQCRDLS GRPASDCAKE LKPNDVRPCA
     DTPCPRWQLG NWSPCSKTCG KGFKKRLLKC ISFDGTILTH ENCDLSKKPK HLIDFCNVTL
     CS
//
DBGET integrated database retrieval system